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ENTPD3 is similar to E-type nucleotidases (NTPases). Additionally we are shipping Ectonucleoside Triphosphate diphosphohydrolase 3 Proteins (7) and Ectonucleoside Triphosphate diphosphohydrolase 3 Kits (1) and many more products for this protein.
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expressed in zebrafish hypocretin (show OX Antibodies) cells as previously reported in mammals, also in the cranial nerves (gV, gVII, gIV (show CCDC88A Antibodies) and gX) and in primary sensory neurons (i.e., Rohon-Beard neurons) in the spinal cord
NTPDase2 (show ENTPD2 Antibodies) and -3 are ecto (show TRIM33 Antibodies)-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut (show GUSB Antibodies) inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease.
Despite the increased level of NTPDase1 (show ENTPD1 Antibodies) and NTPDase3 mRNA expression in chondrogenically induced MSCs, their activity toward ATP remains quite low.
NTPDase3 is the major ectonucleotidase in pancreatic beta-cells in multiple species and modulates insulin (show INS Antibodies) secretion by controlling activation of purinergic receptors.
Cystic fibrosis (show S100A8 Antibodies) epithelia exhibit >50% lower NTPDase1 (show ENTPD1 Antibodies) activity, protein, and mRNA levels than normal epithelia, whereas these parameters are threefold higher for NTPDase3.
NTPDase3 sequence revealed a high degree of structural fold similarity with a bacterial exopolyphosphatase
efficiently inhibit the NTPDase3expressed in insulin (show INS Antibodies) secreting human pancreatic islet cells in situ
Generation of a helical model for NTPDase3 suggests the importance of putative hydrogen bond interactions of conserved polar residues which are critical for enzyme expression, activity, and its susceptibility to membrane perturbations.
Results identified the expression of ecto (show TRIM33 Antibodies)-NTPDase3 in trigeminal nociceptive neurons and demonstrated the presence of functional ecto-ATPase (show CEACAM1 Antibodies) activity in trigeminal nerves and established that ecto (show TRIM33 Antibodies)-NTPDase3mediates extracellularATP degradation in the nociceptive lamina on the brainstem.
Mesenteric endothelial cells are primed by schistosomiasis to a pro-inflammatory phenotype characterized by an increased expression of NTPDases 2 and 3, favoring ADP accumulation and mononuclear cell adhesion, possibly contributing to mesenteric inflammation and schistosomiasis morbidity via P2Y1 receptor (show P2RY1 Antibodies) signaling.
The results of this study proposeed that NTPDase3 is a key regulator of nociceptive signaling that also makes an unexpected contribution to innocuous tactile sensation.
the specific localization of NTPDase3 in the digestive system suggests functional roles of the enzyme, in association with NTPDase2 (show ENTPD2 Antibodies) and ecto-5'-nucleotidase (show ACPP Antibodies), in epithelial functions such as secretion and in enteric neurotransmission.
ENTPD3 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD3 contains 4 apyrase-conserved regions which is characteristic of NTPases.
ectonucleoside triphosphate diphosphohydrolase 3
, ecto-nucleosidase triphosphate diphosphohydrolase 3
, ecto-nucleoside triphosphate diphosphohydrolase 3
, ectonucleoside triphosphate diphosphohydrolase 3-like
, CD39 antigen-like 3
, CD39-like 3
, NTPDase 3
, ecto-ATP diphosphohydrolase 3
, ecto-ATPDase 3
, ecto-ATPase 3
, ecto-apyrase 3