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ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. Additionally we are shipping Electron-Transfer-Flavoprotein, alpha Polypeptide Antibodies (126) and Electron-Transfer-Flavoprotein, alpha Polypeptide Proteins (8) and many more products for this protein.
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Data suggest that ETF (heterodimer of ETFA and ETFB) catalyzes irreversible and pH-dependent oxidation of 8alpha-methyl group of FAD to form to 8-formyl-FAD (8f-FAD).
our results indicate that genetic variants in ETFA may modify individual susceptibility to non-GBM of glioma in the Han Chinese population and support the role of the ETFA genes in the occurrence of glioma.
the mechanism of tert-butyl hydroperoxide-induced an apoptosis cascade and endoplasmic reticulum stress in hepatocyte cells by up-regulation of ETFA, providing a new mechanism for liver injury.
These results are consistent with the electron transfer flavoprotein alpha II domain adopting orientations in solution that deviate from the crystal structure of free ETF towards the active, substrate-bound orientation.
investigations are compatible with the notion that the ETFalpha-T171 variant displays an altered conformational landscape that results in reduced protein function under thermal stress
Data established structural hotspots within the ETF fold, and provided a rationale for the prediction of effects of mutations in ETF.
These studies indicate that a series of conformational changes occur during the assembly of the TMADH.ETF electron transfer complex and that the kinetics of assembly observed with mutant TMADH or ETF complexes are much slower
Tissue samples from 16 unrelated patients with ETF deficiency were analysed and the majority of the patients had mutations in the ETFA gene.
No mutations in electron-transfer-flavoprotein but maternal riboflavin deficiency led to multiple acyl-CoA dehydrogenation deficiency
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene.
electron transfer flavoprotein, alpha polypeptide
, electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II)
, electron transfer flavoprotein subunit alpha, mitochondrial
, electron-transfer-flavoprotein, alpha polypeptide
, electron-transfer-flavoprotein alpha polypeptide
, mitochondrial electron transfer flavoprotein subunit alpha
, electron transferring flavoprotein, alpha polypeptide
, electron transfer flavoprotein alpha-subunit
, glutaric aciduria II
, electron transfer flavoprotein alpha-subunit, mitochondrial
, electron transfer flavoprotein alpha subunit