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EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001. Additionally we are shipping Endomucin Proteins (10) and Endomucin Kits (6) and many more products for this protein.
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Mouse (Murine) Polyclonal EMCN Primary Antibody for CyTOF, FACS - ABIN4899620
Ramo, Sugamura, Craige, Keaney, Davis: Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. in eLife 2016
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Mouse (Murine) Monoclonal EMCN Primary Antibody for FACS, IP - ABIN2192211
Kuhn, Brachtendorf, Kurth, Sonntag, Samulowitz, Metze, Vestweber: Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin. in The Journal of investigative dermatology 2002
Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin.
In contrast, endomucin (EMCN) is present on the lymphatic sinus endothelium and not on lymphatic endothelium of the subcapsular sinus. Moreover, both murine and human MSR1 on lymphatic endothelium of the SS bind lymphocytes and in in vivo studies MSR1 regulates entrance of lymphocytes from the SS to the lymph node parenchyma
These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation.
A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis.
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001
, gastric cancer antigen Ga34
, mucin 14, endothelial