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EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Endomucin Antibodies (66) and Endomucin Kits (3) and many more products for this protein.
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In contrast, endomucin (EMCN) is present on the lymphatic sinus endothelium and not on lymphatic endothelium of the subcapsular sinus. Moreover, both murine and human MSR1 (show MSR1 Proteins) on lymphatic endothelium of the SS bind lymphocytes and in in vivo studies MSR1 (show MSR1 Proteins) regulates entrance of lymphocytes from the SS to the lymph node parenchyma
These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation.
A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis.
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001
, gastric cancer antigen Ga34
, mucin 14, endothelial