Endoplasmic Reticulum Aminopeptidase 2 Proteins (ERAP2)

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Additionally we are shipping Endoplasmic Reticulum Aminopeptidase 2 Antibodies (33) and Endoplasmic Reticulum Aminopeptidase 2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ERAP2 64167 Q6P179
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Top Endoplasmic Reticulum Aminopeptidase 2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Log in to see 15 to 18 Days

ERAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

More Proteins for Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Interaction Partners

Human Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) interaction partners

  1. this study shows the association of ERAP2 single nucleotide polymorphism and its haplotypes with psoriasis vulgaris, and its dependence on the presence or absence of the HLA-C*06:02 allele and age at disease onset

  2. ERAP1 and ERAP2 heterodimers have a role in mediating the processing pathway of MHC class I antigens

  3. These results indicated that the ERAP gene may play a critical role in HCV chronicity in this Chinese Han population

  4. ERAP1 and ERAP2 have significant and distinct effects on the HLA-B*27 peptidome, suggesting that both enzymes largely act as separate entities in vivo. This may explain their different patterns of association with AS.

  5. This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 (show ERAP1 Proteins) and ERAP2 polymorphisms on their enzymatic activity.

  6. ERAP2 deficiency causes increased MHC class I free heavy chain expression and up-regulation of the unfolded protein response pathway in anklyosing spondylitis.

  7. ERAP-2 significantly influences the B*27:05-bound peptidome by destroying some ligands and decreasing the abundance of many more ligands with N-terminal basic residues, while increasing the abundance of nonamers. The former effects are best explained by direct ERAP-2 trimming. The effects on peptide length might be attributed to ERAP-2-induced activation of ERAP-1 (show ERAP1 Proteins) trimming. These data support the notion of a peptide-media

  8. study reveals fine-mapped AID risk variants that act as eQTLs with ERAP2 in thymus

  9. there is a significant association of ERAP2 with psoriatic arthritis and HLA-B27 negative psoriatic arthritis, while ERAP1 association is restricted only to HLA-B27 positive disease

  10. Increased expression of ERAP2 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.

Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Protein Profile

Protein Summary

Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2\; MIM 190470) (Tanioka et al., 2003

Gene names and symbols associated with ERAP2

  • endoplasmic reticulum aminopeptidase 2 (ERAP2)
  • endoplasmic reticulum aminopeptidase 2 (erap2)
  • ERAP2 protein
  • L-RAP protein
  • LRAP protein
  • zgc:172163 protein

Protein level used designations for ERAP2

leukocyte-derived arginine aminopeptidase , endoplasmic reticulum aminopeptidase 2 , endoplasmic reticulum aminopeptidase 2-like

64167 Homo sapiens
461959 Pan troglodytes
513572 Bos taurus
700118 Macaca mulatta
100171433 Pongo abelii
100402550 Callithrix jacchus
100856345 Canis lupus familiaris
100073223 Equus caballus
100525036 Sus scrofa
100144556 Danio rerio
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