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The protein encoded by ECSCR is primarily found in endothelial cells and blood vessels, where it may be involved in cell shape changes and EGF-induced cell migration. Additionally we are shipping and and many more products for this protein.
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Low expression level of ECSCR is associated with evasive resistance and disease progression in cancer.
Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR (show KDR ELISA Kits)) activation and promotes proteolysis of internalized KDR (show KDR ELISA Kits).
ECSM2 modulated bFGF-directed endothelial cell motility via the FGF receptor (FGFR)-extracellular regulated kinase (ERK)-focal adhesion kinase (FAK) pathway.
Characterize a novel cell surface protein (show CD28 ELISA Kits) ECSM2 that regulates endothelial chemotaxis and tube formation, and interacts with filamin A (show FLNA ELISA Kits).
ECSM2 is involved in cell-shape changes and actin cytoskeletal rearrangement, suppresses tyrosine phosphorylation signaling and ECSM2 can cross-talk with EGFR (show EGFR ELISA Kits) to attenuate the EGF (show EGF ELISA Kits)-induced cell migration.
Knockdown of ARIA in HUVECs significantly reduced endothelial apoptosis without affecting either cell migration or proliferation. ARIA knockdown significantly increased inhibitor of apoptosis cIAP-1 and cIAP-2 protein expression
these results suggest that ECSCR plays a critical function in regulating lipolysis in white adipose tissue.
two mouse ECSCR splicing variants/isoform precursors exist and are differentially expressed in a variety of tissue types and likely involved in modulation of vascular Endothelial cell migration.
These studies, revealed a previously undescribed mode of manipulating cardiac PI3K/Akt (show AKT1 ELISA Kits) signaling by ARIA, thus identifying it as an attractive new target for the prevention of stress-induced myocardial dysfunction.
Inactivation of Ecscr enhances insulin (show INS ELISA Kits) sensitivity and may represent a new therapeutic strategy for treating metabolic syndrome.
ARIA was expressed in blood vessels during mouse embryogenesis, as well as in endothelial cells both in vitro and in vivo.
The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it may be involved in cell shape changes and EGF-induced cell migration. This gene could play a role in angiogenesis-related diseases.
apoptosis regulator through modulating IAP expression
, endothelial cell-specific chemotaxis regulator
, endothelial cell-specific molecule 2