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May have a role in the cell cycle.. Additionally we are shipping ERH Antibodies (70) and ERH Kits (4) and many more products for this protein.
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Data suggest that ERH interacts directly in nucleus with C-terminal Arg-Gly-rich region of SAFB1/SAFB2 and this multimer co-localizes in insoluble nuclear fraction; binding of ERH reverses inhibition exerted by SAFB1/SAFB2 on SRPK1. (ERH = enhancer of rudimentary homolog protein; SAFB = scaffold attachment factor B; SRPK1 = splicing kinase SR protein kinase-1)
ERH regulation of RNA processing is needed to ensure faithful DNA replication and repair.
REVIEW: recent findings indicate that ERH plays an important role in cell cycle through its mRNA splicing activity and is critically required for genomic stability and cancer cell survival
Identification of amino acid residues of ERH required for its recruitment to nuclear speckles and replication foci
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
ERH contributes to chromosome alignment at the metaphase plate by localizing CENP-E (show CENPE Proteins) at kinetochore regions.
ERH may be an important transcription regulator that also functions in the control of cell-cycle progression.
interaction with ERH could block the binding of p21(Cip1/Waf1 (show CDKN1A Proteins)) by Ciz1 (show CIZ1 Proteins) in the cell. When ERH and Ciz1 (show CIZ1 Proteins) are coexpressed in HeLa cells, Ciz1 (show CIZ1 Proteins) recruits ERH to DNA replication foci
Enhancer of rudimentary homolog (ERH) overexpression may be implicated in the initiation and/or progression of certain human malignancies.
Through expression studies and utilizing a transgenic Msi1 (show MSI1 Proteins) testis-specific (show AIF1 Proteins) overexpression model, we have identified 2 unique RNA-binding targets of MSI1 (show MSI1 Proteins) in spermatogonia, Msi2 (show MSI2 Proteins) and Erh, and have demonstrated a role for MSI1 (show MSI1 Proteins) in translational regulation.
May have a role in the cell cycle.
enhancer of rudimentary homolog
, enhancer of rudimentary homolog (Drosophila)
, enhancer of rudimentary homolog A
, enhancer of rudimentary homologue ERH
, preimplantation protein 1