Eosinophil Peroxidase Proteins (EPX)

EPX is a member of the peroxidase gene family and is expressed in eosinophils. Additionally we are shipping EPX Antibodies (119) and EPX Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EPX 8288 P11678
EPX 13861 P49290
Rat EPX EPX 303414  
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Top EPX Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,626.73
Details
Human Human Un-conjugated 50 μg Log in to see 2 to 3 Days
$755.00
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$696.46
Details
Human Human Un-conjugated   200 μg Log in to see 2 to 3 Days
$1,331.00
Details

EPX Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine) ,

More Proteins for Eosinophil Peroxidase (EPX) Interaction Partners

Xenopus laevis Eosinophil Peroxidase (EPX) interaction partners

  1. tyrosine phosphorylation of PMR1 is required for the targeting and degradation of polyribosome-bound substrate mRNA

Human Eosinophil Peroxidase (EPX) interaction partners

  1. peroxidase enzymes, like MPO and EPO, may play a fundamental role in inhibiting RANKL-induced osteoclast differentiation at inflammatory sites of bone fracture and injury.

  2. Both MPO and EPO are causatively involved in breast cancer progression and identified as potential therapeutic targets whereby specific novel inhibitors may reduce tumor growth and limit the occurrence of metastasis.

  3. The main significance of this work is the discovery of EPO as a novel ligand for the HER2 receptor. Following HER2 activation, EPO induces activation of FAK and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 and the HER2 receptor

  4. EPO-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma.

  5. there is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum.

  6. Myeloperoxidase and eosinophil peroxidase are readily internalized by HUVEC cells where they promote cellular proliferation, migration, invasion, and stimulate angiogenesis both in vitro and in vivo.

  7. A preferential role of EPO signaling via a specific surface receptor that leads to neural plasticity.

  8. mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation.

  9. Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia.

  10. report the prevalence of a common SNP in the eosinophil protein x/eosinophil-derived neurotoxin (EPX/EDN, RNase2) and the association with the cellular contents of EPX/EDN and ECP

  11. Polymorphisms of EPX and ECP are associated to inflammatory bowel disease in an age and gender dependent manne.

  12. Data indicate that eosinophil peroxidase (EPX)-based ELISA is the only eosinophil-specific assay.

  13. A mechanism of induction of ASIC-3 expression relevant to AR was suggested by the finding that eosinophil peroxidase (EPO), acting via ERK1/2, induced the expression of ASIC-3 in epithelial cells.

  14. HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation.

  15. EPO-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders

  16. induces surface alteration, killing, and lysis of Mycobacterium tuberculosis

  17. results suggest that Pro358Leu in EPO is strongly involved in the development of cedar pollinosis

  18. Polymorphisms of the eosinophil peroxidase gene may be associated with Japanese cedar pollinosis.

  19. Analysis of the role of thiocyanate (SCN-), in modulating the catalytic activity of myeloperoxidase (MPO) and other members of the lactoperoxidase (LPO) and eosinophil peroxidase (EPO)

  20. The mechanisms by which eosinophil peroxidase oxidizes nitrite are reported.

Mouse (Murine) Eosinophil Peroxidase (EPX) interaction partners

  1. The expression of MBP-1 and EPX was also required for induced lung expression of IL-4/IL-13 in each setting and, in turn, the induced pulmonary remodeling events and lung dysfunction.

  2. EPO-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma.

  3. The absence of MBP-1 and EPX promoted a concomitant loss of eosinophil lineage-committed progenitors in the marrow, identifying a specific blockade in eosinophilopoiesis as the causative event.

  4. HER2 was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation.

  5. Host protection against Brugia pahangi infections was unimpaired in mice deficient in eosinophil peroxidase.

  6. Mice deficient for either eosinophil peroxidase or major basic protein on the 129/SvJ background developed significantly higher worm burdens than wild-type mice.

  7. post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase

  8. The activities of EPO, an eosinophilic secondary granule protein, do not affect the development of allergic pulmonary pathologies in the mouse lung at levels comparable to those observed in humans with asthma.

EPX Protein Profile

Protein Summary

This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency.

Gene names and symbols associated with Eosinophil Peroxidase Proteins (EPX)

  • eosinophil peroxidase (LOC788751)
  • eosinophil peroxidase (EPX)
  • eosinophil peroxidase L homeolog (epx.L)
  • eosinophil peroxidase (Epx)
  • EPO protein
  • EPP protein
  • EPX protein
  • EPX-PEN protein
  • pmr-1 protein

Protein level used designations for Eosinophil Peroxidase Proteins (EPX)

eosinophil peroxidase , polysomal ribonuclease 1 , eosinophil peroxidase-like

GENE ID SPECIES
788751 Bos taurus
468420 Pan troglodytes
491109 Canis lupus familiaris
709655 Macaca mulatta
398084 Xenopus laevis
100437241 Pongo abelii
100473148 Ailuropoda melanoleuca
8288 Homo sapiens
13861 Mus musculus
303414 Rattus norvegicus
100514365 Sus scrofa
Selected quality suppliers for EPX Proteins (EPX)
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