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EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]..
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Avoiding damage formation through invalidation of Mus81 (show MUS81 Proteins)-Eme2 and Mre11 (show MRE11A Proteins), or preventing damage signaling by turning off the ATM (show ATM Proteins) pathway, suppresses the replication phenotypes of Chk1 (show CHEK1 Proteins)-deficient cells.
Results define distinct and temporal roles for MUS81 (show MUS81 Proteins)-EME1 and MUS81 (show MUS81 Proteins)-EME2 in the maintenance of genome stability.
The presence of a 5' phosphate terminus at nicks and gaps rendered DNA significantly less susceptible to the cleavage by MUS81 (show MUS81 Proteins)-EME2 than its absence.
The results indicate that MUS81-EME2 is a more active endonuclease than MUS81-EME1 and exhibits broader substrate specificity.
EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007
essential meiotic endonuclease 1 homolog 2
, probable crossover junction endonuclease EME2
, essential meiotic endonuclease 1 homolog 2 (S. pombe)
, SLX2 structure-specific endonuclease subunit homolog B
, homolog of yeast EME1 endonuclease 2