Essential Meiotic Endonuclease 1 Homolog 2 (S. Pombe) Proteins (EME2)

EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]..

list all proteins Gene Name GeneID UniProt
Rat EME2 EME2 302982  
Mouse EME2 EME2 193838 Q56A04
Human EME2 EME2 197342 A4GXA9
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Top EME2 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details

More Proteins for Essential Meiotic Endonuclease 1 Homolog 2 (S. Pombe) (EME2) Interaction Partners

Human Essential Meiotic Endonuclease 1 Homolog 2 (S. Pombe) (EME2) interaction partners

  1. Avoiding damage formation through invalidation of Mus81 (show MUS81 Proteins)-Eme2 and Mre11 (show MRE11A Proteins), or preventing damage signaling by turning off the ATM (show ATM Proteins) pathway, suppresses the replication phenotypes of Chk1 (show CHEK1 Proteins)-deficient cells.

  2. Results define distinct and temporal roles for MUS81 (show MUS81 Proteins)-EME1 and MUS81 (show MUS81 Proteins)-EME2 in the maintenance of genome stability.

  3. The presence of a 5' phosphate terminus at nicks and gaps rendered DNA significantly less susceptible to the cleavage by MUS81 (show MUS81 Proteins)-EME2 than its absence.

  4. The results indicate that MUS81-EME2 is a more active endonuclease than MUS81-EME1 and exhibits broader substrate specificity.

EME2 Protein Profile

Protein Summary

EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007

Gene names and symbols associated with EME2

  • essential meiotic structure-specific endonuclease subunit 2 (Eme2)
  • essential meiotic structure-specific endonuclease subunit 2 (EME2)
  • 2810013J18Rik protein
  • gs125 protein
  • RGD1304924 protein
  • SLX2B protein

Protein level used designations for EME2

essential meiotic endonuclease 1 homolog 2 , probable crossover junction endonuclease EME2 , essential meiotic endonuclease 1 homolog 2 (S. pombe) , SLX2 structure-specific endonuclease subunit homolog B , homolog of yeast EME1 endonuclease 2

GENE ID SPECIES
302982 Rattus norvegicus
416400 Gallus gallus
467868 Pan troglodytes
515662 Bos taurus
722482 Macaca mulatta
193838 Mus musculus
197342 Homo sapiens
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