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EI24 has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. Additionally we are shipping Etoposide Induced 2.4 Antibodies (61) and and many more products for this protein.
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EI24 is an essential player in ubiquitin-proteasome system-autophagy crosstalk via degradation of RING E3 ligases.
Low EI24 expression is associated with triple negative breast cancer.
Low EI24 and high IGF-1R expressions in lung cancer patients.
Findings establish EI24 as a critical suppressor of tumor progression.
Ei24 can bind specifically to IMPbeta1 and IMPalpha2 to impede their normal role in nuclear import.
Ei24 is a novel E2F1 target gene contributing to the survival of p53-deficient cells upon UVC irradiation and thus may have a potential significance as a therapeutic target of certain chemotherapy for treating p53-deficient tumors.
our data suggest that inactivation of EI24 and CHEK1 through two independent mechanisms contributes to the development of CACX.
LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance.
identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness
Ei24 is a regulator of the RINCK1-PKCalpha-EGFR signaling pathway in the development of skin-cancer.
Ei24 is an essential autophagy gene and plays an important role in clearance of aggregate-prone proteins in neurons and hepatocytes.
Studies identified 61 novel potential mEi24 interacting proteins.
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.
ectopic P-granules autophagy protein 4 homolog
, etoposide induced 2.4 mRNA
, etoposide-induced protein 2.4 homolog
, p53-induced gene 8 protein
, tumor protein p53 inducible protein 8
, etoposide-induced protein 2.4