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EHF encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs).
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A negative correlation between EHF protein and miR206 expression.
Human prostate tumors with IL-6 (show IL6 Proteins) elevation and loss of ESE3/EHF were associated with STAT3 (show STAT3 Proteins) activation and displayed upregulation of genes related to cell adhesion, cancer stem-like and metastatic spread.
EHF is a novel functional oncogene (show RAB1A Proteins) in thyroid cancer by transcriptionally regulating HER2 (show ERBB2 Proteins) and HER3 (show ERBB3 Proteins), and may represent a potential therapeutic target for this cancer
The role of EHF in modifying Cystic Fibrosis (show S100A8 Proteins) lung disease severity.
is a novel functional oncogene (show RAB1A Proteins) in gastric cancer by regulating the human epidermal growth factor receptor (show EGFR Proteins) (HER) family of receptor tyrosine kinases.
tight control by ESE3/EHF over the Lin28 (show LIN28A Proteins)/let-7 axis is a critical barrier to malignant transformation.
ESE3 as a negative regulator of pancreatic ductal adenocarcinomas (PDAC) progression and metastasis by enforcing E-cadherin (show CDH1 Proteins) upregulation.
EHF activates expression of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet cell hyperplasia.
Results found that EHF was elevated in ovarian cancer tissues and correlated with short survival. Its overexpression in ovarian cancer cells promoted cell growth and metastasis, and inhibited cell apoptosis.
This study suggests that ESE3 plays an important role in the carcinogenesis of Esophageal Squamous Cell Carcinoma through changes in subcellular localization and may act as a tumor suppressor gene in Esophageal Squamous Cell Carcinoma.
These data provide insights into the mechanisms underlying epithelial development and aging, identifying EHF as a regulator of cornea epithelial identity
This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene.
ETS homologous factor
, ESE3 transcription factor
, ETS domain-containing transcription factor
, epithelium-specific Ets transcription factor 3
, ets homologous factor