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ETV1 encodes a member of the ETS (E twenty-six) family of transcription factors.
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four oncogenic ETS (show ETS1 ELISA Kits) (ERG (show ERG ELISA Kits), ETV1, ETV4 (show ETV4 ELISA Kits), and ETV5), and no other ETS (show ETS1 ELISA Kits), interact with the Ewing's sarcoma breakpoint protein, EWS (show EWSR1 ELISA Kits).
Our results indicate that assessing AP1 (show FOSB ELISA Kits) and PEA3 (show ETV4 ELISA Kits) transcription factor status might be a good indicator of OAC status. However, we could not detect any associations with disease stage or patient treatment regime. This suggests that the PEA3 (show ETV4 ELISA Kits)-AP1 (show FOSB ELISA Kits) regulatory module more likely contributes more generally to the cancer phenotype. In keeping with this observation, depletion of ETV1 and/or ETV4 (show ETV4 ELISA Kits) causes an OAC cell growth defect
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1, ETV4 and ETV5.
the prostate cancer-related oncogenic E26 transformation-specific (ETS) transcription factors, ETV1, ETV4, and ETV5, were required for TAZ gene transcription in PC3 prostate cancer cells
C646 treatment attenuated ETV1 protein expression and inactivated KIT-dependent pathways. Taken together, the present study suggests that CBP/p300 (show CREBBP ELISA Kits) may serve as novel antineoplastic targets and that use of the selective HAT inhibitor C646 is a promising antitumor strategy for Gastrointestinal stromal tumors.
these data reveal a JMJD2A (show KDM4A ELISA Kits)/ETV1/YAP1 (show YAP1 ELISA Kits) axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.
conclude that ETV1 is specifically expressed in the majority of gastrointestinal stromal tumors, even in some KIT-negative cases
ETV1 and COP1 are a pair of independent predictors of prognosis for triple-negative breast cancer.
ETV1 overexpression is associated with prostate cancer aggressiveness.
Results show that ETV1 was upregulated at a higher rate in Gastrointestinal stromal tumor and was correlated with KIT expression.
we conclude that Etv1 acts downstream of FGF signaling to regulate the initiation of neurogenesis in the Xenopus retina.
Here, we present a model in which the ETV1 promoter is used to specifically and inducibly drive Cre recombinase (show RAG1 ELISA Kits) in ICC as a strategy to study GIST pathogenesis.
Loss of Etv1 resulted in a complete disruption of the normal sodium current heterogeneity that exists between atrial, VCS (show EDC4 ELISA Kits), and ventricular myocytes.
we described a RET (show RET ELISA Kits)-ER81-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ
Thus, taken into consideration the mechanism that controls the upregulation of maturation genes involved in synaptic formation, these results indicate that Etv1 orchestrates the activity-dependent regulation of both maturation and immaturation genes in developing granule cells and plays a key role in specifying the identity of mature granule cells in the cerebellum.
downstream ETV1/4/5 transcriptional up-regulation appears highly sensitive and specific and can be used as a reliable molecular signature and diagnostic method for CIC (show CIC ELISA Kits) fusion positive SBRCTs
this study shows that network activity dynamically modulates the properties of fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator Er81.
Data showed that ETV1 knockdown reduced KIT expression and GIST proliferation.
both Etv1 and Ewsr1 (show EWSR1 ELISA Kits) were necessary for Fgf10 (show FGF10 ELISA Kits) expression and elongation of the limb bud.
ETV1 appeared to support development of invasive adenocarcinoma under the background of full Pten loss
er81 embryonic expression regulation does not require FGF signalling.
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA
ets variant 1
, ets domain protein
, ets variant gene 1
, ETS translocation variant 1
, ets-related protein 81
, ets-related transcription factor XER81
, ets related protein 81
, ETS transcription factor Er81