anti-Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa (EIF2B5) Antibodies

EIF2B5 encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Additionally we are shipping EIF2B5 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF2B5 224045 Q8CHW4
EIF2B5 192234 Q64350
EIF2B5 8893 Q13144
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Top anti-EIF2B5 Antibodies at antibodies-online.com

Showing 10 out of 42 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis in mouse testis tissue lysates (35ug/lane). EIF2B5 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using EIF2B5 antibody. 200 μL 12 to 14 Days
$438.90
Details
Human Mouse Un-conjugated ELISA, WB EIF2B5 polyclonal antibody (A01), Lot # 060814QCS1 Western Blot analysis of EIF2B5 expression in 293 . EIF2B5 polyclonal antibody (A01), Lot # 060113JC01. Western Blot analysis of EIF2B5 expression in human ovarian cancer. 50 μL 11 to 12 Days
$305.71
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL 11 to 14 Days
$793.83
Details
Human Rabbit Un-conjugated WB Western Blot showing EIF2B5 antibody used at a concentration of 1 ug/ml against U937 Cell Lysate 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit PE IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit HRP IHC, ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

Top referenced anti-EIF2B5 Antibodies

  1. Cow (Bovine) Polyclonal EIF2B5 Primary Antibody for WB - ABIN2788769 : Wortham, Stewart, Harris, Coldwell, Proud: Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits. in The Biochemical journal 2016 (PubMed)

More Antibodies against EIF2B5 Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa (EIF2B5) interaction partners

  1. These results reveal a key role of the AKT-GSK3beta-eIF2Bepsilon signaling module in regulating axon regeneration in the adult mammalian central nervous system.

  2. analysis of eukaryotic initiation factor 2B epsilon phosphorylation sites and ubiquitin-modified lysine residues

  3. Data show that toll-like receptors (TLRs)-TRIF signalling activates eIF2B GEF through PP2A-mediated serine dephosphorylation of the eIF2B varepsilon-subunit.

  4. mouse model of EIF2B-related leukodystrophy; findings provide evidence that hypomorphic Eif2b5 alleles lead to delayed and abnormal development and maintenance of CNS white matter

  5. Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha phosphorylation, reduction of eIF2B activity, and inhibition of eIF4F complex formation.

  6. inactivation of glycogen synthase kinase 3beta (GSK3beta) by high glucose and high insulin induces increase in synthesis of laminin beta1 via activation of eIF2Bepsilon.

Human Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa (EIF2B5) interaction partners

  1. Exon-level analyses classified > 1,000 mRNAs as alternatively spliced under hypoxia and uncovered a unique retained intron (RI) in the master regulator of translation initiation, EIF2B5.

  2. This study demonstrated that no evidence for a role of Ile587Val polymorphism of EIF2B5 gene in multiple sclerosis in Kashmir Valley if India.

  3. Patient exhibits an early-infantile onset and progressive disease course resembling Cree leukoencephalopathy, suggesting a severe functional disruption of eIF2Bepsilon caused by R195H as well as by I408T mutations.

  4. Missense mutations in EIF2B5 are associated with multiple sclerosis.

  5. Also a mutation c.1913G>A[p.Arg638 His] in exon 14 of the EIF2B5-Gens as single nucleotide polymorphism.

  6. crystal structure of the guanine nucleotide exchange factor for elf2

  7. Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bepsilon (eIF2Bepsilon) identified in Chinese patients with vanishing white matter disease

  8. The clinical phenotype in vanishing white matter disease is influenced by the combination of both mutations(p.Arg113His and p.Thr91Ala/p.Arg339any). Females tend to do better than males.

  9. Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus.

  10. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy.

  11. We demonstrated that mutations in the gene EIF2B5 cause "leukoencephalopathy with vanishing white matter." This gene encodes one of the five subunits of the translation factor eIF2B.

  12. Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D), forms complexes with reduced stability and lower eIF2B activity.

  13. mutations in EIF2b5 causes a specific reduction in the generation of GFAP+ astrocytes in vanishing white matter disease

  14. Arg113His mutation in eIF2B5 associated with adult onset of vanishing white matter leukoencephalopathy is not present in multiple sclerosis patients

  15. We describe progressive megalencephaly and severe brain abnormalities due to specific EIF2Bepsilon mutations in two unrelated families.

  16. Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to more than 120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon)

  17. These data support the importance of the non-catalytic domain of the eIF2Bepsilon subunit in the eIF2B complex formation and activity.

  18. no evidence for the involvement of EIF2B5 in multiple sclerosis susceptibility in France

  19. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men.

EIF2B5 Antigen Profile

Protein Summary

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.

Gene names and symbols associated with EIF2B5

  • eukaryotic translation initiation factor 2B subunit epsilon (EIF2B5) antibody
  • eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (EIF2B5) antibody
  • Trimeric LpxA-like enzyme (AT2G34970) antibody
  • Trimeric LpxA-like enzyme (AT3G02270) antibody
  • translation initiation factor eif-2b epsilon subunit (AOR_1_624154) antibody
  • translation initiation factor eIF-2B epsilon subunit (CTRG_05484) antibody
  • translation initiation factor eIF-2B epsilon subunit (PAAG_05066) antibody
  • Translation initiation factor eIF-2B epsilon subunit, putative (CGB_A5380C) antibody
  • translation initiation factor eif-2b epsilon subunit (TERG_01115) antibody
  • eukaryotic translation initiation factor 2B, subunit 5 epsilon (Eif2b5) antibody
  • eukaryotic translation initiation factor 2B subunit epsilon (Eif2b5) antibody
  • AO090003000364 antibody
  • C81315 antibody
  • CACH antibody
  • CLE antibody
  • EIF-2B antibody
  • EIF2B5 antibody
  • EIF2Bepsilon antibody
  • F14P3.8 antibody
  • F14P3_8 antibody
  • F19I3.20 antibody
  • F19I3_20 antibody
  • LVWM antibody

Protein level used designations for EIF2B5

eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa , translation initiation factor eIF-2B subunit epsilon , translation initiation factor eIF-2B subunit epsilon-like , translation initiation factor eIF-2B epsilon subunit , translation initiation factor eif-2b epsilon subunit , eIF-2B GDP-GTP exchange factor subunit epsilon , initiation factor eIF-2Be , eIF-2Bepsilon

GENE ID SPECIES
424948 Gallus gallus
460881 Pan troglodytes
488103 Canis lupus familiaris
703673 Macaca mulatta
783760 Bos taurus
100389722 Callithrix jacchus
100446186 Pongo abelii
100580454 Nomascus leucogenys
818061 Arabidopsis thaliana
821200 Arabidopsis thaliana
5991536 Aspergillus oryzae RIB40
8300542 Candida tropicalis MYA-3404
9096172 Paracoccidioides sp. 'lutzii' Pb01
10187846 Cryptococcus gattii WM276
10373875 Trichophyton rubrum CBS 118892
224045 Mus musculus
192234 Rattus norvegicus
8893 Homo sapiens
100009393 Oryctolagus cuniculus
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