Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Additionally we are shipping EIF4A1 Antibodies (32) and EIF4A1 Proteins (11) and many more products for this protein.
Star-PAP-specific polyadenylation sites usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1.
our data demonstrate that the common effects of eIF4A1 and eIF4E (show EIF4E ELISA Kits) on translation are mediated by the coding region and 3'UTR (show UTS2R ELISA Kits)
our data identify the eIF4F (show EIF4A2 ELISA Kits) complex as an important upstream regulator of TORC1 (show CRTC1 ELISA Kits), which acts via TSC2 (show TSC2 ELISA Kits) to inactivate TORC1 (show CRTC1 ELISA Kits) upon withdrawal of amino acids
Our results demonstrate that miR (show MLXIP ELISA Kits)-133a plays a pivotal role in colorectal cancer by inhibiting cell proliferation, invasion, and migration by targeting oncogenic eukaryotic translation initiation factor 4A1, which acts as a tumor suppressor and may provide a new potential therapeutic target in colorectal cancer
miR (show MLXIP ELISA Kits)-1284 can function as a new regulator to reduce gastric cancer multidrug resistant cells by targeting EIF4A1.
Studies indicate a developing focus on targeting eukaryotic initiation factor 4A (show DDX39 ELISA Kits) eIF4A1 and eIF4A2 (show EIF4A2 ELISA Kits) as cancer therapy.
Immunohistochemical analysis was performed on over 3000 breast tumors to investigate the relationship among expression of eIF4A1, the helicase-modulating proteins eIF4B (show EIF4B ELISA Kits), eIF4E (show EIF4E ELISA Kits) and PDCD4 (show PDCD4 ELISA Kits), and clinical outcome.
Collectively, these data suggested that a potential role of NS4A in antagonizing host antiviral defense is by recruiting eIF4AI and escaping the translation inhibition mediated by PKR (show PKLR ELISA Kits).
eIF4A functions as an adenosine triphosphate-dependent processive helicase when complexed with two accessory proteins, eIF4G (show EIF4G1 ELISA Kits) and eIF4B (show EIF4B ELISA Kits).
demonstrate that DAP5 associates with eIF2beta and eIF4AI to stimulate IRES-dependent translation of cellular mRNAs
the central A-rich domains of BC RNAs target eIF4A, specifically inhibiting its RNA helicase activity
analysis of the tandem MA-3 (show PDCD6 ELISA Kits) region of Pdcd4 (show PDCD4 ELISA Kits) protein and characterization of its interactions with eIF4A and eIF4G (show EIF4G1 ELISA Kits)
Pdcd4 (show PDCD4 ELISA Kits) binding to eIF4A is linked to its transformation-suppressing activity, as Pdcd4 (show PDCD4 ELISA Kits)-eIF4A binding and consequent inhibition of translation are required for Pdcd4 (show PDCD4 ELISA Kits) transrepression of AP-1 (show JUN ELISA Kits).
The binding of pateamine to eIF4A presets the protein in the high-affinity RNA-binding state, which stimulates ATP binding, hydrolysis, and RNA unwinding.
interactions between Pdcd4 (show PDCD4 ELISA Kits) and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G (show EIF4G1 ELISA Kits)
analysis of cells of eIF4GIf molecules lacking either the PABP (show EBP ELISA Kits)-binding site, the eIF3 (show EIF3A ELISA Kits)-binding site, the middle domain eIF4A-binding site, or the C-terminal segment that includes the second eIF4A-binding site
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
translation initiation factor eIF4A I
, eukaryotic translation initiation factor 4A1
, eukaryotic translation initiation factor 4A, isoform 1
, eukaryotic translation initiation factor 4A
, eukaryotic initiation factor 4A-I
, eukaryotic translation initiation factor 4A-like
, eukaryotic initiation factor 4A-I-like
, ATP-dependent RNA helicase eIF4A-1
, eukaryotic initiation factor 4AI
, initiation factor eIF-4A long form