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XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009].. Additionally we are shipping XPO4 Antibodies (16) and XPO4 Proteins (3) and many more products for this protein.
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Molecular structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A has been reported.
XPO4 copy number variation duplication was associated with histological severity of non-alcoholic fatty liver disease.
Knockdown of exportins 4, 5, and 7 altered thyroid hormone receptor shuttling dynamics, and when exportins 5 and 7 were overexpressed, TR distribution shifted toward the cytosol.
Methylation status of XPO4 in peripheral blood mononuclear cells (PBMCs) tended to be a noninvasive biomarker to predict hepatocellular carcinoma (HCC) and the progression of hepatitis B virus (HBV)infection.
These results demonstrate that Exp4 acts as a Sox9 co-regulator that directly regulates binding of Sox9 to its target genes.
Data suggest that XPO4 could be involved in the progression of human hepatocellular carcinoma.
A short peptide representing the minimal interaction domain in Smad3 effectively competes with Smad3 association to exportin 4 and blocks nuclear export of Smad3 in vivo.
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000