Protein Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FXYD5

• FXYD domain containing ion transport regulator 5 (FXYD5) antibody
• FXYD domain-containing ion transport regulator 5 (Fxyd5) antibody

• DYSAD antibody
• EF-8 antibody
• FXYD5 antibody
• IWU1 antibody
• KCT1 antibody
• Show all synonym aliases
• Oit2 antibody
• PRO6241 antibody
• RIC antibody

Protein level used designations for FXYD5

FXYD domain-containing ion transport regulator 5 , FXYD domain containing ion transport regulator 5 , dysadherin , keratinocytes associated transmembrane protein 1 , ion channel homolog RIC , oncoprotein induced transcript 2 , oncoprotein-induced protein 2