FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) ELISA Kits

FXYD5 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. Additionally we are shipping FXYD5 Antibodies (58) and FXYD5 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FXYD5 53827 Q96DB9
FXYD5 18301 P97808
Anti-Rat FXYD5 FXYD5 60338 P59647
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Top FXYD5 ELISA Kits at antibodies-online.com

Showing 2 out of 3 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 9.75 pg/mL 39-2500 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Mouse 0.078 ng/mL 0.312-20 ng/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details

More ELISA Kits for FXYD5 Interaction Partners

Human FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) interaction partners

  1. the ratio between FXYD5 and alpha1-beta1 heterodimer determines whether the Na,K-ATPase acts as a positive or negative regulator of intercellular adhesion.

  2. Knockdown of FXYD5 in MDA-MB-231 breast cancer cells largely decreases expression and secretion of the chemokine CCL2 (MCP-1). A related effect has also been observed in renal cell carcinoma cells.

  3. Study demonstrated that the expression of FXYD1, FXYD3 and FXYD5 is elevated in the lungs of Acute respiratory distress syndrome patients

  4. Dysadherin-silenced side population cells exhibited reduced expression of Bcl-2 and Bax compared with that prior to silencing.

  5. we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer

  6. Findings suggest that dysadherin might contribute to breast cancer progression through AKT activation.

  7. These results suggest a role of let-7a down-regulation in the development of thyroid neoplasias of the follicular histotype, likely regulating dysadherin protein expression levels.

  8. Data show that osteoblasts are the major cell type of the bone marrow that affect RCC cells by secreting factors that increase the expression of dysadherin and CCL2 in the tumor cells leading to enhanced cell migration.

  9. This is the first report on expression of dysadherin in the male gonad and in spermatozoa.

  10. Overexpression of Snail, Slug, and dysadherin and activation of Wnt and PI3K/Akt signaling was associated with inactivated E-cadherin in the spindle cells of monophasic fibrous synovial sarcomas.

  11. Combined dysadherin-positive expression and E-cadherin-negative expression may be valuable information for predicting aggressive tumor behavior of differentiated-type gastric carcinoma with submucosal invasion

  12. transfection of dysadherin cDNA into the liver cancer cell line PLC/PRF/5 enhanced the properties of cencer stem cells, including anti-apoptosis, their sphere-forming ability, side population phenotype, and tumor initiation ability in vivo

  13. In lung carcinomas dysadherin expression seems to reflect tumour aggressiveness and may be considered a positive marker of poor prognosis when considered alone or/and in combination with down-regulation of E-cadherin.

  14. The detection of dysadherin in tumors and cytokeratin in the lymph nodes may be a potential significant indicator of a poor prognosis for patients who undergo complete resection of stage I non-small cell lung cancer

  15. We report the cloning and characterization of a cancer-associated cell membrane glycoprotein recognized by mAb NCC-3G10.

  16. dysadherin expression was significantly associated with the prognosis, occurrence of secondary undifferentiated carcinomas, size of the primary tumor, and metastasis to the regional lymph nodes and lungs

  17. dysadherin has a role in hematogenous metastasis of gastric cancer

  18. Dysadherin and E-cadherin expression may help to predict the prognosis of patients with ESCC (esophageal squamous cell carcinoma).

  19. Dysadherin is able to modulate actin structures, stimulate cell motility, and contribute directly to the metastatic potential of human pancreatic cancer cells.

  20. dysadherin may be a valuable prognostic marker in cervical carcinoma.

Mouse (Murine) FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) interaction partners

  1. FXYD5 mediates metastatic progression through regulation of the beta Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model.

  2. transfection of M1 epithelial cell line with FXYD5 largely increases lipopolysaccharide (LPS) stimulated CCL2 mRNA and secretion of the translated protein

  3. FXYD5 affects cell polarization through its interaction with Na(+)-K(+)-ATPase.

  4. Expressing FXYD5 in mouse kidney collecting duct cell line M1 led to a large decrease in amiloride-insensitive transepithelial electrical resistance as well as increased permeability to 4-kDa dextran.

  5. The role of FXYD5 in Na,K-ATPase activity, its cellular and tissue distribution, and its biochemical properties are reported.

  6. data suggest that different FXYD proteins interact similarly with the Na(+)-K(+)-ATPase and their transmembrane domains

  7. FXYD5 is significantly increased in the lungs and nasal epithelium of cystic fibrosis mice as assessed by RT-PCR.

FXYD5 Antigen Profile

Antigen Summary

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FXYD5

  • FXYD domain containing ion transport regulator 5 (FXYD5) antibody
  • FXYD domain-containing ion transport regulator 5 (Fxyd5) antibody
  • DYSAD antibody
  • EF-8 antibody
  • FXYD5 antibody
  • IWU1 antibody
  • KCT1 antibody
  • Oit2 antibody
  • PRO6241 antibody
  • RIC antibody

Protein level used designations for FXYD5

FXYD domain-containing ion transport regulator 5 , FXYD domain containing ion transport regulator 5 , dysadherin , keratinocytes associated transmembrane protein 1 , ion channel homolog RIC , oncoprotein induced transcript 2 , oncoprotein-induced protein 2

GENE ID SPECIES
505584 Bos taurus
744650 Pan troglodytes
53827 Homo sapiens
18301 Mus musculus
60338 Rattus norvegicus
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