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This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. Additionally we are shipping FXYD7 Proteins (3) and many more products for this protein.
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Intracellular trafficking of FXYD1 (phospholemman (show FXYD1 Antibodies)) and FXYD7 proteins in Xenopus oocytes and mammalian cells.
Expressed in Xenopus oocytes, mouse FXYD7 can interact with Na,K-ATPase alpha 1-beta 1, alpha 2-beta 1 and alpha 3-beta 1 but not with alpha-beta 2 isozymes whereas, in brain, it is only associated with alpha 1-beta isozymes.
FXYD7 is a new member of proteins with a regulated ER export and has a particular regulatory function in brain
the the TM domain of FXYD7 has a role in mediating the complex interactions of FXYD7 with Na,K-ATPase (show ATP1A1 Antibodies)
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein.
FXYD domain-containing ion transport regulator 7