Family with Sequence Similarity 20, Member C (FAM20C) ELISA Kits

FAM20C encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. Additionally we are shipping FAM20C Antibodies (48) and FAM20C Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FAM20C 56975 Q8IXL6
Anti-Mouse FAM20C FAM20C 80752 Q5MJS3
Anti-Rat FAM20C FAM20C 304334  
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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Human 0.094 ng/mL 0.15 ng/mL - 10 ng/mL A typical standard curve 96 Tests 13 to 16 Days

More ELISA Kits for FAM20C Interaction Partners

Human Family with Sequence Similarity 20, Member C (FAM20C) interaction partners

  1. The authors show that endoplasmic reticulum oxidoreductin 1alpha (Ero1alpha), the pivotal sulfhydryl oxidase that catalyzes disulfide formation in the endoplasmic reticulum, is phosphorylated by Fam20C in the Golgi apparatus and retrograde-transported to the endoplasmic reticulum mediated by ERp44.

  2. Study identified a homozygous missense variant c.1228 T > A (p.Ser410Thr) in the exon 6 of FAM20C gene. This mutation is likely pathogenic variant that confirmed the clinical diagnosis of Raine syndrome.

  3. that FAM20C may affect the biomineralization by the means more than local phosphorylation of extracellular matrix proteins and systemic phosphorus homeostasis

  4. Histidine-rich Ca-binding protein (HRC) was phosphorylated by family with sequence similarity 20C (Fam20C) both in vitro and in vivo.

  5. These results suggest that TET1 potentially promotes the cytodifferentiation potential of human dental pulp cells through its DNA demethylation machinery and upregulation of FAM20C protein expression.

  6. findings clarify FAM20C's role in hard tissue formation and mineralization, and show that Raine syndrome is congenital sclerosing osteomalacia with cerebral calcification.

  7. Alterations of Fam20C activity, promoted by myriocin and sphingolipids, are not accompanied by any significant change in Fam20C protein. These data provide the proof of concept that Fam20C activity is under the control of sphingolipid signaling

  8. Our report reinforces that Raine syndrome is compatible with life, and that mild hypophosphatemia and amelogenesis imperfecta are key features of the attenuated form.

  9. Fam20A potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.

  10. The Fam20C-and VLK-family of kinases mediate the phosphorylation of proteins in the secretory pathway and extracellular space.Mutation in several secretory pathway kinases cause human disease

  11. by treating Fam20C expressing HEK293T cells with myriocin, a potent inhibitor of the sphingosine biosynthetic pathway, the activity of Fam20C released into the conditioned medium is substantially decreased corroborating the concept that sphingosine

  12. Using CRISPR/Cas9 genome editing, mass spectrometry, and biochemistry, study identifies more than 100 secreted phosphoproteins as genuine Fam20C substrates; further, study shows that Fam20C exhibits broader substrate specificity than previously appreciated.

  13. phenotype in two families with non-lethal Raine syndrome with FAM20C mutations

  14. Findings suggest that certain homozygous FAM20C mutations can cause FGF23-related hypophosphatemic osteomalacia and indicate the multiple roles of FAM20C in bone.

  15. Results suggest that FAM20C suppresses FGF23 production by enhancing DMP1 expression, and inactivating mutations in FAM20C cause FGF23-related hypophosphatemia by decreasing transcription of DMP1.

  16. We report on a child who is homozygous for a 487-kb deletion in 7p22.3 that contains FAM20C

  17. Fam20C phosphorylates FGF23, which promotes FGF23 proteolysis by furin by blocking O-glycosylation by polypeptide N-acetylgalactosaminyltransferase 3.

  18. mutations in FAM20C provide a putative new mechanism in human subjects leading to dysregulated FGF23 levels, hypophosphatemia, hyperphosphaturia, dental anomalies, intracerebral calcifications and osteosclerosis of the long bones

  19. Our results identify FAM20C as a kinase for secreted phosphoproteins and establish a biochemical basis for Raine syndrome.

  20. Fam20C appears to be the Golgi casein kinase that phosphorylates secretory pathway proteins within S-x-E motifs; Fam20C phosphorylates caseins and several secreted proteins implicated in biomineralization; mutations in Fam20C cause an osteosclerotic bone dysplasia known as Raine syndrome

Mouse (Murine) Family with Sequence Similarity 20, Member C (FAM20C) interaction partners

  1. FAM20C is a key regulator of acinar and duct structure and duct maturation.

  2. These findings indicate that inactivation of Fam20C in cells expressing type I collagen led to skeletal defects and hypophosphatemia.

  3. we show that Fam20C phosphorylates several SR proteins involved in Ca(2+) signaling, including calsequestrin2 and Stim1, whose biochemical activities are dramatically regulated by Fam20C mediated phosphorylation

  4. that Fam20c indeed regulates cell behaviors and cell signaling pathway in a cell-autonomous manner

  5. family with sequence similarity member 20C is the primary, but not the only, kinase for the SIBLINGs

  6. Fam20A potentiates Fam20C kinase activity and promotes the phosphorylation of enamel matrix proteins in vitro.

  7. Loss of Fam20C function leads to periodontal disease in mice

  8. Successful generation of Fam20C-GFP transgenic mice will provide a unique model for studying Fam20C gene expression and the biological function of this gene during odontogenesis and osteogenesis

  9. we have successfully generated the immortalized mouse floxed Fam20c dental papilla mesenchymal and osteoblast cell lines.

  10. These results indicated that the downregulation of Dmp1 may not directly associate with, or significantly contribute to the bone and dentin defects in the Fam20C-cKO mice.

  11. that FAM20C is not a constituent of the enamel extracellular matrix and functions intracellularly within ameloblasts.

  12. FAM20C is a molecule essential to amelogenesis, its inactivation in the dental epithelium does not significantly affect dentinogenesis.

  13. FAM20C is essential to the differentiation and mineralization of dental tissues through the regulation of molecules critical to the differentiation of tooth-formative cells.

  14. Our findings indicate that FAM20C is essential to the differentiation of osteoblasts/osteocytes and is involved in the regulation of phosphate homeostasis via the mediation of FGF23

  15. Fam20c null mice develop hypophosphatemic rickets and defective enamel and dentin

  16. temporospatial expression profile of FAM20C

  17. This study defines the causative role of FAM20C in this lethal osteosclerotic disorder and its crucial role in normal bone development.

FAM20C Antigen Profile

Antigen Summary

This gene encodes a member of the family with sequence similarity 20 (FAM20) family of secreted proteins. A similar gene in mice encodes a protein that plays a role in dentin mineralization, and mutations in the human gene are associated with the autosomal recessive disorder Raine syndrome.

Gene names and symbols associated with FAM20C

  • FAM20C, golgi associated secretory pathway kinase (FAM20C) antibody
  • family with sequence similarity 20, member C (FAM20C) antibody
  • family with sequence similarity 20, member C (Fam20c) antibody
  • FAM20C, golgi associated secretory pathway kinase (Fam20c) antibody
  • family with sequence similarity 20, member Cb (fam20cb) antibody
  • C76981 antibody
  • DMP-4 antibody
  • DMP4 antibody
  • GEF-CK antibody
  • mKIAA4081 antibody
  • RGD1311980 antibody
  • RNS antibody
  • si:ch73-266a4.1 antibody

Protein level used designations for FAM20C

family with sequence similarity 20, member C , dentin matrix protein 4 , extracellular serine/threonine protein kinase FAM20C , golgi-enriched fraction casein kinase , fam20c2

100231802 Taeniopygia guttata
100342945 Oryctolagus cuniculus
416445 Gallus gallus
56975 Homo sapiens
491596 Canis lupus familiaris
80752 Mus musculus
304334 Rattus norvegicus
560397 Danio rerio
534672 Bos taurus
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