-
we found that there was a significant association between FSCN1 expression and poor relapse-free survival and overall survival. Therefore, we suggest that co-targeting epidermal growth factor receptor and FSCN1 dual biomarker may be used as a novel therapeutic strategy for triple-negative breast cancer.
-
genetic variations in the FSCN1 gene may serve as an important predictor of early-stage breast cancer.
-
we found that ZEB1-AS1 is a downstream target of TGF-beta1 and is involved in its regulatory mechanism on cell migration and invasion by affecting miR-200b/FSCN1 axis in bladder cancer cells
-
Study demonstrated that Fascin-1 expression correlates with poor patient survival and can be used as an additional prognostic factor for osteosarcoma patient outcome.
-
FSCN1 is a driver of invasiveness in renal cell carcinoma cells via PI3 K/AKT signaling axis.
-
Through stimulation with cancerassociated fibroblasts and growth factors, study demonstrated that fascin expression was regulated by stromal factors of the microenvironment surrounding the tumor. A fascindepleted cell line showed low RhoA and NFkappaB activity suggesting that RhoA and NFkappaB signals are involved in fascin expression.
-
Fascin is important for Rab25-induced breast and ovarian cancer invasion.
-
esults indicate that the inhibition of autophagy and exogenous expression of fascin-1 may promote the invasiveness of endometrial cells.
-
fascin1 constitutively interacts with IkappaB kinase (IKK) in the RIG-I signaling pathway. In summary, we have identified fascin1 as a suppressor of the RIG-I signaling pathway associating with IkappaB kinase in DLD-1 colon cancer cells to suppress immune responses to viral infection.
-
fascin protein accumulation, caused by reduced proteasomal activity, contributes to the acquisition of cancer stemness in chronic inflammation-related colon carcinogenesis.
-
Fascin1 is related with clinicopathologic parameters of gastric cancer and overexpressed both in gastric cell lines and gastric tumor tissue
-
the expression of Fascin_1 protein differed between cancer tissue and paracarcinoma tissues in NSCLC patients and it was also correlated with poor prognosis.
-
FSCN1 physiologically interacted with and increased the levels of snail1 to promote ovarian cancer cell epithelial-mesenchymal transition .
-
fascin1 is an important mediator of TGF-beta1-induced invasion and migration of kidney carcinoma cells through ERK and JNK signal pathways.
-
findings demonstrate that fascin is required for migration and invasion induced by LA in MDA-MB-231 breast cancer cells.
-
PCAT-1 accelerated prostate cancer cell proliferation, migration, invasion and suppressed apoptosis by up-regulating FSCN1 mediated via miR-145-5p.
-
Lentivirus-mediated fascin-1 knockdown significantly decreased the proliferation of non-small cell lung cancer cells. Furthermore, fascin-1 silencing partly inhibited cell invasion and migration. Inhibition of fascin-1 decreased the activity of the MAPK pathway.
-
Study shows that Fascin 1 has a nuclear function in the regulation of the amino-acid transporter SLC3A2.
-
SNAI2 overexpression significantly increased FSCN1 expression at both mRNA and protein level. FSCN1 overexpression reduced the expression of E-cadherin and Claudin 1, but increased the expression of Vimentin and N-cadherin in SCC9 and SCC-15 cells. It is inferred that FSCN1 is a downstream effector of SNAI2 in promoting EMT in HNSC cells.
-
MYC-nick, fascin, and Cdc42 are frequently up-regulated in cells present at the invasive front of human colorectal tumors, suggesting a coordinated role for these proteins in tumor migration.