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anti-Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) Antibodies

FSCN1 encodes a member of the fascin family of actin-binding proteins. Additionally we are shipping Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Kits (30) and Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteins (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FSCN1 14086 Q61553
FSCN1 683788 P85845
FSCN1 6624 Q16658
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Top anti-Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Antibodies at antibodies-online.com

Showing 10 out of 215 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of Fascin Antibody (Center) (ABIN390697) in Y79 cell line lysates (35 µg/lane). Fascin (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma with Fascin Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: HeLa B: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1 to 2 Days
$358.60
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brainstem with Anti-Fascin1 Polyclonal Antibody, Unconjugated (ABIN728293) at 1:300, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric carcinoma with Anti-Fascin1 Polyclonal Antibody, Unconjugated (ABIN728293) at 1:300, followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, PE conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$306.90
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western Blot: Fascin Antibody [NBP1-32708] - Sample (30 ug of whole cell lysate)A: HeLa B: Hep G2 7.5% SDS PAGE; antibody diluted at 1:1000. Western Blot: Fascin Antibody - Wild-type (WT) and Fascin 1 knownout (KO) HeLa cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Fascin 1 antibody , Internal. HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced. 0.1 mL Log in to see 7 to 9 Days
$514.63
Details
Dog Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-phospho-FSCN1(Ser39) Polyclonal Antibody, Unconjugated (ABIN673011) at 1:200 followed by conjugation to the secondary antibody and DAB staining Image kindly submitted by Dr. Magdalena Krol. Control canine mammary tumor cells, tumor cells cultured in macrophage-conditioned medium, and co-cultured with macrophages were seeded on Lab-Tek slides (previously coated with Matrigel) for 72 h. The cells were then washed two times in warm PBS and were fixed in 3.7% paraformaldehyde for 20 min at room temperature. Subsequently, the cells were permeabilized with 0.5% Triton X-100 diluted in PBS for 10 min at room temperature, washed three times in PBS, and incubated with rabbit anti-phospho-fascin (FSCN1, Ser39) antibodies diluted 1:100 in PBS (Bioss). After overnight incubation with primary antibodies at 4uC, the cells were washed three times in PBS, incubated with secondary Alexa Fluor 568 goat anti-rabbit antibodies (diluted 1:500 in PBS) for 1 h in the dark at room temperature. Coverslips were then mounted on microscope slides using mounting medium (Sigma Aldrich). Cell imaging was performed using a confocal laser scanning microscope FV-500 system (Olympus Optical Co) with a 488-nm argon laser and 505- to 525-nm filter for FITC staining and with a 543-nm He-Ne laser and a 610-nm filter for Alexa Fluor 568 staining. Images were gathered separately for each fluorescence channel, and the cells were examined using the Fluoview program (Olympus Optical Co.) 100 μL Log in to see 3 to 7 Days
$340.45
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Rat Brain, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$181.73
Details

FSCN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Antibodies

  1. Dog (Canine) Polyclonal FSCN1 Primary Antibody for IF (p), IHC (p) - ABIN673011 : Majchrzak, Lo Re, Gajewska, Bulkowska, Homa, Paw?owski, Motyl, Murphy, Król: Migrastatin analogues inhibit canine mammary cancer cell migration and invasion. in PLoS ONE 2013 (PubMed)
    Show all 3 Pubmed References

  2. Dog (Canine) Polyclonal FSCN1 Primary Antibody for WB - ABIN610551 : Attramadal, Arriza, Aoki, Dawson, Codina, Kwatra, Snyder, Caron, Lefkowitz: Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. in The Journal of biological chemistry 1992 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal FSCN1 Primary Antibody for WB - ABIN442669 : Law, Li, Chou, Chen, Chan: Hyaluronic acid-dependent protection in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. in Toxicology 2013 (PubMed)

More Antibodies against Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Interaction Partners

Fruit Fly (Drosophila melanogaster) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.

  2. essential for actin bundle initiation and stiffening during embryonic tracheal system development

  3. Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.

  4. Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.

  5. These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling

  6. The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.

  7. The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.

  8. Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.

  9. Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.

  10. study found that Rab35 (show RAB35 Antibodies) regulates the assembly of actin (show ACTB Antibodies) filaments during bristle development; effect was mediated by the a (show ACTB Antibodies)ctin-bundling protein fascin, which directly associated with active R (show RAB35 Antibodies)ab35

Zebrafish Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation

Mouse (Murine) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. Filopodia formation by crosslinking of F-actin with fascin in two different binding manners

  2. Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.

  3. Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3 (show MAP1LC3A Antibodies), an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.

  4. A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.

  5. fascin 1 promotes cell migration and has a role in growth and cell cycle progression

  6. Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia (show KAT6B Antibodies) RAW264.7 macrophages.

  7. Both STAT3 (show STAT3 Antibodies) and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.

  8. fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development

  9. We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.

  10. Fascin is a novel target of beta-catenin (show CTNNB1 Antibodies)-TCF (show HNF4A Antibodies) signaling and is expressed at the invasive front of human colon cancer

Human Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. SNAI2 overexpression significantly increased FSCN1 expression at both mRNA and protein level. FSCN1 overexpression reduced the expression of E-cadherin (show CDH1 Antibodies) and Claudin 1 (show CLDN7 Antibodies), but increased the expression of Vimentin (show VIM Antibodies) and N-cadherin (show CDH2 Antibodies) in SCC9 and SCC (show CYP11A1 Antibodies)-15 cells. It is inferred that FSCN1 is a downstream effector of SNAI2 in promoting EMT (show ITK Antibodies) in HNSC cells.

  2. MYC (show MYC Antibodies)-nick, fascin, and Cdc42 (show CDC42 Antibodies) are frequently up-regulated in cells present at the invasive front of human colorectal tumors, suggesting a coordinated role for these proteins in tumor migration.

  3. The prognostic importance of TGF-beta (show TGFB1 Antibodies), TGF-beta (show TGFB1 Antibodies) receptor, and fascin in childhood solid tumors

  4. The results reveal that phosphorylation at FSCN1 amino acids Y23, S38, S39 and S274, in combination, downregulates the extent of anchorage-independent growth, cell migration and filopodia formation in esophageal squamous cancer cells.

  5. Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.

  6. This study showed that fascin expression intensity may be correlated with clinical outcomes of a newly diagnosed primary glioblastoma.

  7. These data demonstrated fascin as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch (show NOTCH1 Antibodies) self-renewal signaling pathway.

  8. These results suggest that strong positive fascin-1 expression can be used as a diagnostic marker of TNBC.

  9. Authors demonstrated that one miRNA, miR (show MLXIP Antibodies)-29a-5p, can bind to both the XIAP (show XIAP Antibodies) and FSCN1 3'UTRs and play an important role in that interactions. We showed that the 3'UTR (show UTS2R Antibodies) of XIAP (show XIAP Antibodies) was able to antagonize miR (show MLXIP Antibodies)-29a-5p, and resulted in the increased translation of XIAP (show XIAP Antibodies) and FSCN1.

  10. The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer.

Pig (Porcine) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

  1. FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.

Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) Antigen Profile

Protein Summary

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.

Gene names and symbols associated with FSCN1

  • singed (sn) antibody
  • fascin actin-bundling protein 1 (fscn1) antibody
  • fascin actin-bundling protein 1a (fscn1a) antibody
  • fascin actin-bundling protein 1 (Fscn1) antibody
  • fascin actin-bundling protein 1 L homeolog (fscn1.L) antibody
  • fascin actin-bundling protein 1 (FSCN1) antibody
  • AI663989 antibody
  • CG1536 antibody
  • CG15331 antibody
  • CG32858 antibody
  • Dmel\\CG32858 antibody
  • FAN1 antibody
  • fascin antibody
  • fascin-1 antibody
  • fs(1)A1057 antibody
  • fs(1)K418 antibody
  • fs(1)K473 antibody
  • fs(1)K743 antibody
  • fs(1)K1421 antibody
  • fs(1)M45 antibody
  • fscn antibody
  • fscn1 antibody
  • HSN antibody
  • MGC75811 antibody
  • p55 antibody
  • sb:cb589 antibody
  • Sn antibody
  • SNL antibody
  • zgc:153632 antibody

Protein level used designations for FSCN1

CG32858-PA , CG32858-PB , CG32858-PD , CG32858-PE , CG32858-PF , CG32858-PG , fascin , sn-PA , sn-PB , sn-PD , sn-PE , sn-PF , sn-PG , fascin-1 , fascin 1 , singed-like protein , 55 kDa actin-bundling protein , singed-like (fascin homolog, sea urchin)

GENE ID SPECIES
31717 Drosophila melanogaster
394733 Xenopus (Silurana) tropicalis
558271 Danio rerio
14086 Mus musculus
683788 Rattus norvegicus
397934 Xenopus laevis
6624 Homo sapiens
489880 Canis lupus familiaris
100286741 Sus scrofa
100733694 Cavia porcellus
507342 Bos taurus
416485 Gallus gallus
101108186 Ovis aries
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