anti-Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) Antibodies

Fruit Fly (Drosophila melanogaster) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

1. Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.

2. essential for actin bundle initiation and stiffening during embryonic tracheal system development

3. Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.

4. Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.

5. These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling

6. The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.

7. The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.

8. Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.

9. Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.

10. study found that Rab35 regulates the assembly of actin filaments during bristle development; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35

Zebrafish Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

1. Fscn1 acts as a molecular linker between TGF-beta family type I receptors and the actin filaments to promote the trafficking of internalized receptors from clathrin-coated vesicles to early endosomes during zebrafish endoderm formation.

2. These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation

Mouse (Murine) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

1. Fascin-1 is specifically expressed in podocytes.

2. MAGE-G1 interacted with fascin 1 or vimentin in P19 cells after a 6-day retinoic acid-induced neuronal differentiation.

3. The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression.

4. Filopodia formation by crosslinking of F-actin with fascin in two different binding manners

5. Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.

6. Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3, an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.

7. A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.

8. fascin 1 promotes cell migration and has a role in growth and cell cycle progression

9. Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia RAW264.7 macrophages.

10. Both STAT3 and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.

11. Fascin1 is critical for cell migration; expression of exogenous fascin1 in fascin1-null dendritic cells (DC) rescues the defects in membrane protrusive activity, as well as in DC podosome disassembly.

12. fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development

13. We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.

14. Fascin is a novel target of beta-catenin-TCF signaling and is expressed at the invasive front of human colon cancer

15. Fascin mRNA & protein levels were significantly lower in the cultured ANXA2(-/-) cells than in cultured ANXA2(+/+) cells. ANXA2 may be an inducer or enhancer of fascin expression at the transcription level.

16. The results indicate that fascin1-mediated filopodia assembly is dispensable for mouse development.

17. study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35

Human Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

1. we found that there was a significant association between FSCN1 expression and poor relapse-free survival and overall survival. Therefore, we suggest that co-targeting epidermal growth factor receptor and FSCN1 dual biomarker may be used as a novel therapeutic strategy for triple-negative breast cancer.

2. genetic variations in the FSCN1 gene may serve as an important predictor of early-stage breast cancer.

3. we found that ZEB1-AS1 is a downstream target of TGF-beta1 and is involved in its regulatory mechanism on cell migration and invasion by affecting miR-200b/FSCN1 axis in bladder cancer cells

4. Study demonstrated that Fascin-1 expression correlates with poor patient survival and can be used as an additional prognostic factor for osteosarcoma patient outcome.

5. FSCN1 is a driver of invasiveness in renal cell carcinoma cells via PI3 K/AKT signaling axis.

6. Through stimulation with cancerassociated fibroblasts and growth factors, study demonstrated that fascin expression was regulated by stromal factors of the microenvironment surrounding the tumor. A fascindepleted cell line showed low RhoA and NFkappaB activity suggesting that RhoA and NFkappaB signals are involved in fascin expression.

7. Fascin is important for Rab25-induced breast and ovarian cancer invasion.

8. esults indicate that the inhibition of autophagy and exogenous expression of fascin-1 may promote the invasiveness of endometrial cells.

9. fascin1 constitutively interacts with IkappaB kinase (IKK) in the RIG-I signaling pathway. In summary, we have identified fascin1 as a suppressor of the RIG-I signaling pathway associating with IkappaB kinase in DLD-1 colon cancer cells to suppress immune responses to viral infection.

10. fascin protein accumulation, caused by reduced proteasomal activity, contributes to the acquisition of cancer stemness in chronic inflammation-related colon carcinogenesis.

11. Fascin1 is related with clinicopathologic parameters of gastric cancer and overexpressed both in gastric cell lines and gastric tumor tissue

12. the expression of Fascin_1 protein differed between cancer tissue and paracarcinoma tissues in NSCLC patients and it was also correlated with poor prognosis.

13. FSCN1 physiologically interacted with and increased the levels of snail1 to promote ovarian cancer cell epithelial-mesenchymal transition .

14. fascin1 is an important mediator of TGF-beta1-induced invasion and migration of kidney carcinoma cells through ERK and JNK signal pathways.

15. findings demonstrate that fascin is required for migration and invasion induced by LA in MDA-MB-231 breast cancer cells.

16. PCAT-1 accelerated prostate cancer cell proliferation, migration, invasion and suppressed apoptosis by up-regulating FSCN1 mediated via miR-145-5p.

17. Lentivirus-mediated fascin-1 knockdown significantly decreased the proliferation of non-small cell lung cancer cells. Furthermore, fascin-1 silencing partly inhibited cell invasion and migration. Inhibition of fascin-1 decreased the activity of the MAPK pathway.

18. Study shows that Fascin 1 has a nuclear function in the regulation of the amino-acid transporter SLC3A2.

19. SNAI2 overexpression significantly increased FSCN1 expression at both mRNA and protein level. FSCN1 overexpression reduced the expression of E-cadherin and Claudin 1, but increased the expression of Vimentin and N-cadherin in SCC9 and SCC-15 cells. It is inferred that FSCN1 is a downstream effector of SNAI2 in promoting EMT in HNSC cells.

20. MYC-nick, fascin, and Cdc42 are frequently up-regulated in cells present at the invasive front of human colorectal tumors, suggesting a coordinated role for these proteins in tumor migration.

Pig (Porcine) Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) (FSCN1) interaction partners

1. FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.