anti-Fascin Homolog 2, Actin-Bundling Protein, Retinal (Strongylocentrotus Purpuratus) (FSCN2) Antibodies

Mouse (Murine) Fascin Homolog 2, Actin-Bundling Protein, Retinal (Strongylocentrotus Purpuratus) (FSCN2) interaction partners

1. These results demonstrate that, in C57BL/6Jmice, Fscn2 is essential for maintaining ear and eye function and that a null mutation of Fscn2 leads to progressive hearing loss and retinal degeneration.

2. The results show that cross-talk through CD40-CD40L signaling drives elevated fascin expression in DCs to support acquisition of full T-cell responses.

3. A quantitative trait locus on chromosome 5 modifies hearing loss associated with the fascin-2 variant of DBA/2J mice.

4. Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.

5. The results of this study demonistrated that fascin-2 crosslinks function to slow actin depolymerization at stereocilia tips to maintain stereocilia length.

6. Mutation in the Fscn2 gene underlies the early onset progressive hearing loss of DBA/2J mice attributed to the ahl8 locus.

Human Fascin Homolog 2, Actin-Bundling Protein, Retinal (Strongylocentrotus Purpuratus) (FSCN2) interaction partners

1. Fascin induces melanoma tumorigenesis and stemness through regulating the Hippo pathway

2. diffuse expression in 82% of undifferentiated/dedifferentiated endometrial carcinomas

3. Tax-mediated transcriptional induction of Fascin requires NF-kappaB- and TRR-dependent promoter activation, and a promoter-independent, but PP2-sensitive signaling pathway.

4. the serum fascin level is an effective indicator of tumor aggressiveness, and that it plays an important role in the prognosis of NSCLC, particularly for non-distant metastatic patients.

5. Data indicate the specific contribution of fascin and cortactin during invadopodium formation.

6. The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin

7. Fascin expression predicts survival after potentially curative resection of node-positive colon cancer.

8. The 208delG mutation in the FSCN2 gene produces not only autosomal dominant retinitis pigmentosa but also ADMD (autosomal dominant macular degeneration)

9. The photoreceptor-specific FSCN2 gene showed a relatively high number of sequence variations.

10. The 208delG mutation in FSCN2 is not associated with hereditary retinal degeneration in the Chinese individuals examined.

11. Real-time PCR-based genotyping method developed here is useful for investigations of allelic asymmetries within genomic regions with variations found in retinitis pigmentosa and retinl degeneration.

12. In ovarian tumors fascin is associated with certain features of increased tumor aggressiveness.

13. Higher fascin scores correlated positively with tumor differentiation of esophageal SqCC. Significantly worse prognosis in patients with high scores of fascin, poor differentiation, T4 stage, positive for lymph node metastasis and distant metastasis

14. expression may play an essential role in regulation of progression of oral squamous cell carcinoma and contributes to the event of epithelial-mesenchymal transition in the early aggressiveness of OSCC