Fc Receptor, IgA, IgM, High Affinity (FCAMR) ELISA Kits

Human Fc Receptor, IgA, IgM, High Affinity (FCAMR) interaction partners

1. A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.

2. rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN.

3. A significantly worse survival was found in patients with IgA serum levels>2.85 g/l compared to patients with lower IgA serum levels.

4. ADAM10 and ADAM17 are involved in the shedding of FcalphaR

5. LPS, through the TLR4 receptor, activates the p38MAPK and NF-kappaB pathways and up-regulate the expression of Fcamr in human macrophages

6. These results suggest that the cytoplasmic portion is required for the dimer formation and thus for efficient cell surface expression of Fcalpha/microR.

7. Comprehensive survey of naturally occurring polymorphisms in rhesus macaques and in humans.

8. These results indicate for the first time that Fcalpha/muR protein is expressed by human intestinal tissues

9. the cytoplasmic portion of human Fcalpha/microR is required in the internalization.

Mouse (Murine) Fc Receptor, IgA, IgM, High Affinity (FCAMR) interaction partners

1. These results reveal a critical role for FcmuR in the survival and activation of marginal zone B cells and in protection against acute bacterial infection.

2. Toll-like receptor 4 (TLR4) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR) for its oligomer formation and interleukin-6 (IL-6) production from marginal zone (MZ) B cells.

3. Serum IgA production against gut-oriented antigens is negatively regulated by Fcalpha/muR on follicular dendritic cells in the F1 mice.

4. These results suggest that Fcalpha/muR enhances, rather than suppresses, autoantibody production.

5. Data suggest that Fcalpha/muR does not form homodimers, but forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa.

6. A significant portion of the effector function of IgM, especially with regard to the enhancement of humoral immune responses and suppression of autoimmunity, is mediated by FcmuR.

7. Mice deficient in Fc alpha/muR have enhanced germinal center formation and affinity maturation and memory induction of IgG3(+) B cells after immunization with T-independent antigens.[Fc alpha/muR]

8. expressed in oligodendrocytes, their precursor cells, and myelin