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Functions as a receptor for the Fc fragment of IgA and IgM. Additionally we are shipping FCAMR Antibodies (9) and FCAMR Proteins (7) and many more products for this protein.
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A genome-wide trans-ethnic interaction study links the PIGR (show PIGR ELISA Kits)-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.
rs3125923 FCAMR gene represents a validated SNP to predict grade 3-4 Taxane-induced peripheral neuropathy . Genetically determined AA race represents the most significant predictor of TIPN.
A significantly worse survival was found in patients with IgA (show IgA ELISA Kits) serum levels>2.85 g/l compared to patients with lower IgA (show IgA ELISA Kits) serum levels.
ADAM10 (show ADAM10 ELISA Kits) and ADAM17 (show ADAM17 ELISA Kits) are involved in the shedding of FcalphaR
LPS, through the TLR4 (show TLR4 ELISA Kits) receptor, activates the p38MAPK (show MAPK14 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) pathways and up-regulate the expression of Fcamr in human macrophages
These results indicate for the first time that Fcalpha/muR (show FCER2 ELISA Kits) protein is expressed by human intestinal tissues
Toll-like receptor 4 (TLR4 (show TLR4 ELISA Kits)) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR (show FCER2 ELISA Kits)) for its oligomer formation and interleukin-6 (IL-6 (show IL6 ELISA Kits)) production from marginal zone (MZ) B cells.
Serum IgA (show IgA ELISA Kits) production against gut (show GUSB ELISA Kits)-oriented antigens is negatively regulated by Fcalpha/muR (show FCER2 ELISA Kits) on follicular dendritic cells in the F1 mice.
These results suggest that Fcalpha/muR (show FCER2 ELISA Kits) enhances, rather than suppresses, autoantibody production.
Data suggest that Fcalpha/muR (show FCER2 ELISA Kits) does not form homodimers, but forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa.
A significant portion of the effector function of IgM, especially with regard to the enhancement of humoral immune responses and suppression of autoimmunity, is mediated by FcmuR.
Mice deficient in Fc alpha/muR have enhanced germinal center formation and affinity maturation and memory induction of IgG3(+) B cells after immunization with T-independent antigens.[Fc alpha/muR]
Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
Fc receptor, IgA, IgM, high affinity
, Fc alpha/mu receptor
, high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
, high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor-like
, immunity related factor
, receptor for Fc fragment of IgA and IgM
, Fc IgA/IgM receptor
, Fca/m receptor
, fc alpha/mu receptor