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Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Additionally we are shipping and many more products for this protein.
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Here we demonstrate that of the nine FGFR1 (show FGFR1 Antibodies) mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Data indicate that fgf20a, fgf24, FGF receptor (show FGFR2 Antibodies) fgfr1 (show FGFR1 Antibodies) are expressed in normal and regenerating barbel tissue.
Shroom3 (show SHROOM3 Antibodies) is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
fgfr (show FGFR2 Antibodies) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.
we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1 (show FGFR1 Antibodies)).
knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration
Bmp and Fgf signaling are essential for liver specification in zebrafish.
The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Antibodies) and its receptors, fgfr1 (show FGFR1 Antibodies) and fgfr4 (show FGFR4 Antibodies), using combined spectroscopy methods are reported.
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol- 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity).
, basic fibroblast growth factor receptor 1-A
, fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1-A