Fibulin 5 Proteins (FBLN5)

The protein encoded by FBLN5 is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. Additionally we are shipping Fibulin 5 Antibodies (155) and Fibulin 5 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FBLN5 10516 Q9UBX5
FBLN5 23876 Q9WVH9
FBLN5 29158 Q9WVH8
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Top Fibulin 5 Proteins at antibodies-online.com

Showing 9 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
$723.00
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$768.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$340.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,184.50
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,184.50
Details

FBLN5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus) ,

Top referenced Fibulin 5 Proteins

  1. Human Fibulin 5 Protein expressed in HEK-293 Cells - ABIN2721183 : Sideek, Menz, Parsi, Gibson: LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis. in Matrix biology : journal of the International Society for Matrix Biology 2014 (PubMed)

More Proteins for Fibulin 5 (FBLN5) Interaction Partners

Human Fibulin 5 (FBLN5) interaction partners

  1. study reports the first Chinese family with c.1117C>T mutation of FBLN5; findings confirm a novel subtype of autosomal-dominant Charcot-Marie-Tooth disease due to a mutation in the FBLN5 gene

  2. The results showed a significant upregulation of ECM1 and ITGB3, and a significant downregulation for FBLN5 in pelvic organ prolapse patients.

  3. Serum fibulin-5 concentration can be regarded as a biomarker for evaluating disease severity and predicting prognosis in intracerebral hemorrhage patients.

  4. Fibulin-5 expression is increased in the induced sputum of asthmatic patients.

  5. Data show that fibulin-5 strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1/TIE-2 receptor axis.

  6. FBLN5 downregulation in human abdominal aortic aneurysm could contribute to extracellular matrix remodeling induced by the inflammatory component of the disease.

  7. Identify a SOX9/HDAC-dependent mechanism involved in the down-regulation of FBLN5 by inflammation in abdominal aortic aneurysms.

  8. We also found that Fibulin-5 reduces the level of expression of Ki-67, a nuclear protein associated with cell proliferation. Moreover, reduction in Fibulin-5 expression corresponds to an increase of Ki-67 detection in breast tissue samples

  9. study demonstrates the pivotal role of the extracellular protein, fibulin-5, on the adhesion and proliferation of human keloid-derived cells, through binding to integrin beta-1

  10. Lower FBLN-5 expression is an important indicator of poor survival in hepatocellular carcinoma. FBLN-5 inhibits HCC adhesion/motility via integrin-dependent mechanism.

  11. FBLN5 mRNA expression is upregulated in response to cAMP-mediated decidualization of primary human endometrial stromal cells, although FBLN5 itself does not enhance decidualization

  12. Fibulin-5 is significantly down-regulated in ovarian carcinoma and acts as a tumour suppressor by inhibiting the migration and invasion of ovarian cancer cells.

  13. Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce ROS production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease.

  14. Data suggest that fibulin-5 functions as a metastasis suppressor in lung cancer by modulating tumor microenvironment to suppress Wnt/beta-catenin signaling.

  15. Fibulin-5 may be implicated in the aetiology of rectal prolapse in a subgroup of young male patients.

  16. Fibulin-5 expression is a disease marker of hepatic fibrosis.

  17. Loss of FBLN5 expression is associated with glioma.

  18. Up-regulation of elastin and fibulin-5 mRNA levels in ICA were strongly correlated with family history of cardiovascular disease when compared to CCA

  19. Data suggest that expression of FBLN5 (fibulin 5) and LOXL1 (lysyl oxidase-like protein 1) (but not expression of elastin) is down-regulated in uterosacral ligaments of postmenopausal women with pelvic organ prolapse.

  20. These results indicate that Fibulin-5 inhibits hepatocellular carcinoma invasion and metastasis by suppressing matrix metalloproteinase-7 expression.

Mouse (Murine) Fibulin 5 (FBLN5) interaction partners

  1. Fibulin-5 overexpression promoted the proliferation and migration of airway smooth muscle cell.

  2. Fibulin-5 overexpression significantly down-regulated the phosphorylation level of eIF2alpha and subsequently inhibited the TRPV1 channel and CREB/CGRP signaling

  3. therapy-induced hypoxia elevated Fbln5 expression, whereas pharmacologic inhibition of TGF-beta signaling reduced Fbln5 expression. These findings offer insight into the signaling axis that induces Fbln5 expression in PDA and a potential strategy to block its production

  4. Identify a SOX9/HDAC-dependent mechanism involved in the down-regulation of FBLN5 by inflammation in abdominal aortic aneurysms.

  5. involved in the stiffening of fibrotic tissue

  6. Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce ROS production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease.

  7. While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative.

  8. Fibulin-5 plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. (Review)

  9. These results are consistent with a role for TGFbeta2 in lung septation and for Ltbp4 in regulating fibulin-5 dependent elastic fiber assembly.

  10. Without LTBP-4, fibulin-5 and tropoelastin deposition was discontinuous and punctate in vitro and in vivo

  11. This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries.

  12. suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility

  13. MMP9 and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans

  14. mechanical testing and confocal imaging of common carotid arteries from fibulin-5 null mice and littermate controls to characterize the mechanical behavior and microstructural content of these arteries

  15. These findings introduce a novel function for Fbln5 in the regulation of integrin-induced reactive oxygen species production.

  16. Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury

  17. Fibulin-5 is a calcium-dependent, elastin-binding protein that localizes to the surface of elastic fibres in vivo.

  18. FBLN-5 is a novel TGF-beta-inducible target gene that regulates cell growth and motility in a context-specific manner and affects protein kinase activation by TGF-beta.

  19. coordinately expressed and regulated with elastin in lung fibroblasts and may serve a key role during lung injury and repair.

  20. EcSOD-fibulin-5 interaction is needed for ecSOD binding to vascular tissues, regulating their O2*- levels. This is a new mechanism for controlling vascular redox state in the extracellular space in cardiovascular diseases with high oxidative stress.

Cow (Bovine) Fibulin 5 (FBLN5) interaction partners

  1. These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers.

Fibulin 5 (FBLN5) Protein Profile

Protein Summary

The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).

Gene names and symbols associated with Fibulin 5 Proteins (FBLN5)

  • fibulin 5 (fbln5)
  • fibulin 5 (FBLN5)
  • fibulin 5 (Fbln5)
  • A55 protein
  • ADCL2 protein
  • ARCL1A protein
  • ARMD3 protein
  • DANCE protein
  • DKFZp469K0327 protein
  • EVEC protein
  • FBLN5 protein
  • FIBL-5 protein
  • Fibulin-5 protein
  • MGC108414 protein
  • UP50 protein
  • zgc:103575 protein

Protein level used designations for Fibulin 5 Proteins (FBLN5)

fibulin-5 , fibulin 5 , fibulin-5-like , developmental arteries and neural crest EGF-like protein , urine p50 protein , FIBL-5 , EVEC , dance , embryonic vascular EGF repeat-containing protein

GENE ID SPECIES
449806 Danio rerio
453112 Pan troglodytes
595007 Xenopus (Silurana) tropicalis
697372 Macaca mulatta
100172278 Pongo abelii
100222931 Taeniopygia guttata
100392828 Callithrix jacchus
100480209 Ailuropoda melanoleuca
100588580 Nomascus leucogenys
10516 Homo sapiens
480227 Canis lupus familiaris
23876 Mus musculus
29158 Rattus norvegicus
535185 Bos taurus
100347343 Oryctolagus cuniculus
100715192 Cavia porcellus
100155248 Sus scrofa
423413 Gallus gallus
101112927 Ovis aries
100063331 Equus caballus
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