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GPR22 is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. Additionally we are shipping GPR22 Antibodies (73) and GPR22 Proteins (3) and many more products for this protein.
Study identified the Gas6 (show GAS6 ELISA Kits)/TAM (show CCNA1 ELISA Kits) receptor pathway with Tyro3 (show TYRO3 ELISA Kits) and Mer (show MERTK ELISA Kits) as novel targets in colorectal cancer.
These results show that TYRO3 (show TYRO3 ELISA Kits), AXL (show AXL ELISA Kits) and GAS6 (show GAS6 ELISA Kits) are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients.
Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 (show TYRO3 ELISA Kits) and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 (show TYRO3 ELISA Kits) and Mer (show MERTK ELISA Kits) expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 (show TYRO3 ELISA Kits) and Mer (show MERTK ELISA Kits) mRNA and increased shedding of sTyro3 and sMer.
TYRO3 (show TYRO3 ELISA Kits) is overexpressed in the early stage of colon cancer development and aberrant expression of TYRO3 (show TYRO3 ELISA Kits) promotes tumorigenesis and induces EMT (show ITK ELISA Kits) through the regulation of SNAI1 (show SNAI1 ELISA Kits).
In this paper, we review the biology of the Gas6 (show GAS6 ELISA Kits)/Tyro3 (show TYRO3 ELISA Kits), Axl (show AXL ELISA Kits), and MerTK (show MERTK ELISA Kits)(collectively named TAM (show CCNA1 ELISA Kits) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
these data suggest that Tyro3 (show TYRO3 ELISA Kits) contributes significantly to tumor growth, aggressiveness and liver dysfunction
Tyro3 (show TYRO3 ELISA Kits) gene dosage modulates Mertk (show MERTK ELISA Kits)-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 (show TYRO3 ELISA Kits) in RPE phagocytosis, and suggest that an eQTL (show EQTN ELISA Kits) can modify a recessive Inherited photoreceptor degenerations.
The mRNA expression levels of Tyro-3 (show TYRO3 ELISA Kits), Axl (show AXL ELISA Kits) were decreased in pSS (show CDSN ELISA Kits) patients. When considering the plasma level, increased levels of soluble Mer (show MERTK ELISA Kits) was observed with statistically significant difference.
genetic ablation of a receptor tyrosine kinase (show RET ELISA Kits) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
the results of the present study demonstrated that the acquired taxol resistance of ovarian cancer cells was associated with ROS (show ROS1 ELISA Kits)-dependent upregulation in the expression of Tyro3 (show TYRO3 ELISA Kits) RTK and the subsequent activation of Akt (show AKT1 ELISA Kits).
Demonstrate GRR22 expression in mouse heart. Identified a protective role for GPR22 in response to hemodynamic stress resulting from increased afterload.
Gpr22 does not act upstream of the two cilia master regulators, Foxj1a and Rfx2 (show RFX2 ELISA Kits).
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
probable G-protein coupled receptor 22
, tyrosine-protein kinase DTK
, tyrosine-protein kinase RSE
, tyrosine-protein kinase SKY
, tyrosine-protein kinase TIF
, tyrosine-protein kinase byk
, tyrosine-protein kinase receptor TYRO3
, G protein-coupled receptor 22