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Orphan receptor.. Additionally we are shipping GPR37L1 Kits (7) and GPR37L1 Proteins (6) and many more products for this protein.
Showing 10 out of 83 products:
Human Polyclonal GPR37L1 Primary Antibody for IHC (p) - ABIN636877
Ehrenreich, Nau, Dembowski, Hasselblatt, Barth, Hahn, Schilling, Sirén A-L, Brück: Endothelin b receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus. in Neuroscience 2000
These findings provide evidence linking GPR37L1 and GPR37 to seizure etiology and demonstrate an association between a homozygous variant in GPR37L1 (c.1047G>T [Lys349Asn]) and a novel progressive myoclonus epilepsy.
Data show that G protein (heterotrimeric guanine nucleotide-binding protein (show COASY Antibodies))-coupled receptor (GPR37L1) coupled to the G protein Galpha (show SUCLG1 Antibodies)(s) when heterologously expressed in cultured cells.
GPR37 (show GPR37 Antibodies) and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin (show PSAP Antibodies).
This study demonstrated that GPR37L1 protects neurons during ischemia, presumably by modulating extracellular glutamate (show GRIN1 Antibodies) concentration and NMDAR (show GRIN1 Antibodies) activation.
K349N substitution in Gpr37L1 did not grossly alter receptor expression, surface trafficking or constitutive signaling in transfected cells. In vivo studies revealed that a complete loss of Gpr37L1 function in mice results in increased seizure susceptibility. Mice lacking the related receptor Gpr37 (show GPR37 Antibodies) also exhibited an increase in seizure susceptibility, while genetic deletion of both receptors resulted greater vulnerability
Gpr37l1 participates in the regulation of sonic hedgehog (show SHH Antibodies) signaling during postnatal cerebellar development.
G protein-coupled receptor 37 like 1
, G-protein coupled receptor 37 like 1
, endothelin B receptor-like protein 2-like
, G-protein coupled receptor 37-like 1
, endothelin B receptor-like protein 2
, endothelin type b receptor-like protein 2
, G protein-coupled receptor 37-lke 1
, endothelin B receptor-like protein-2
, orphan Gpr37-like protein 1
, G-protein coupled receptor CNS2