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Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM, Jul 2002].. Additionally we are shipping and many more products for this protein.
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Human Polyclonal GPR52 Primary Antibody for WB - ABIN1881387
Sawzdargo, Nguyen, Lee, Lynch, Cheng, Heng, George, ODowd: Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. in Brain research. Molecular brain research 1999
Data show that G protein-coupled receptor 52 (Gpr52) modulates huntingtin protein (Htt) levels in the striatal cells in vitro and in vivo.
This study demonstrated that the Knocking-out Gpr52 significantly reduces mutant HTT levels in the striatum and rescues Huntington's disease-associated behavioural phenotypes in a knock-in Huntington's disease mouse model expressing endogenous mutant Htt.
GPR52 has the potential of being a therapeutic psychiatric receptor.
Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.
probable G-protein coupled receptor 52
, G protein-coupled receptor 52
, probable G-protein coupled receptor 52-like