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Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Additionally we are shipping GPR84 Proteins (6) and many more products for this protein.
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we show functional similarities but also some important differences between GPR84 and FFA2R (show FFAR2 Antibodies) in human phagocytes, thus providing some mechanistic insights into GPR84 regulation in blood neutrophils and cells recruited to an aseptic inflammatory site in vivo.
Data suggest that cytokines TNFalpha (show TNF Antibodies) and interleukin-1b markedly reduce GPR120/FFAR4 (show O3FAR1 Antibodies) expression in adipocytes; in contrast, these cytokines induce expression of GPR84 and GPR41/FFAR3 (show FFAR3 Antibodies) in adipocytes. These studies were conducted in adipocytes cultured from subcutaneous adipose tissue. (GPR (show ALDH18A1 Antibodies) = G-protein coupled receptor (show ADRA1A Antibodies); FFAR = free fatty acid receptor)
concluded that diindolylmethane was a positive allosteric modulator for GPR84
A previously unrecognized role of GPR84 in maintaining fully developed acute myeloid leukemia (show BCL11A Antibodies) by sustaining aberrant beta-catenin (show CTNNB1 Antibodies) signaling in leukemic stem cells.
Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.
GPR84 functions as a negative regulator of osteoclastogenesis by inhibiting NF-kappaB (show NFKB1 Antibodies) and MAPK (show MAPK1 Antibodies) signaling pathways.
We conclude that GPR84 plays a beneficial role in amyloid pathology by acting as a sensor for a yet unknown ligand that promotes microglia recruitment, a response affecting dendritic degeneration and required to prevent further cognitive decline.
We found that lipopolysaccharide-stimulated GPR84 knockout macrophages exhibited attenuated expression of several proinflammatory mediators.
As GPR84 plays a role in the biology of myeloid cells, it could be relevant to consider the existence of this mutation when choosing a mouse model to study immune processes, and to consider reevaluating data obtained using such strains.
primary stimulation of T cells with anti-CD3 (show CD3E Antibodies) resulted in increased interleukin-4 (show IL4 Antibodies) but not interleukin-2 (show IL2 Antibodies) or interferon -gamma (show IFNG Antibodies) production in GPR84(-/-) mice compared to wild-type mice
in mice suffering from endotoxemia, microglia express GPR84 in a strong and sustained manner
Fibroblast growth factor signaling requires Xmig6 (show ERRFI1 Antibodies) for muscle differentiation in Xenopus embryos. Fibroblast growth factor signaling may involve XGPCR4 in gastrulation.
Data demonstrates that GPR84 is necessary in the retina for proper development of the retina, as well as other eye tissues including the lens and cornea.
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system (By similarity).
G-protein coupled receptor 84
, inflammation-related G protein-coupled receptor EX33
, inflammation-related G-protein coupled receptor EX33
, orphan G protein-coupled receptor 84
, G protein-coupled receptor 84
, G-protein coupled receptor 84-like