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GPRASP1 encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. Additionally we are shipping G Protein-Coupled Receptor Associated Sorting Protein 1 Antibodies (39) and G Protein-Coupled Receptor Associated Sorting Protein 1 Kits (8) and many more products for this protein.
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Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1
Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2 (show DRD2 Proteins)) are involved in regulation of DRD2 (show DRD2 Proteins) endocytosis by GRK2 (G-protein coupled receptor kinase 2 (show ADRBK1 Proteins)) and GASP1.
GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas.
GASP-1 is a key regulator of the trafficking and, by extension, functional expression of GPR55 (show GPR55 Proteins)
LIR (show CD300C Proteins) was able to induce gains in 1RM and quadriceps CSA (show ERCC8 Proteins) similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN (show MSTN Proteins) and increase in FLST isoforms, GASP-1, and SMAD-7 (show SMAD7 Proteins) mRNA gene expression.
These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer.
following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR (show TAS1R3 Proteins))-associated sorting protein-1 (GASP-1)
identified a protein that binds preferentially to the cytoplasmic tail of the delta opioid receptor as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor (show ADRA1A Proteins)-associated sorting protein (GASP) [GASP]
Modulation of the D2-GASP interaction is important for the functional down-regulation of D2 dopamine receptors.
present the First low resolution solution structure of myostatin (show MSTN Proteins)-free and myostatin (show MSTN Proteins)-bound states of GASP-1 and GASP-2 (show WFIKKN1 Proteins)
Gasp-1 overexpression resulted in increased myostatin (show MSTN Proteins) expression.
GASP-1 and GASP-2 (show WFIKKN1 Proteins) are important modulators of GDF-11 (show GDF11 Proteins) and MSTN (show MSTN Proteins) activity in vivo.
Overexpression of Gasp1 led to an increase in muscle mass observed not before day 15 of postnatal life.
The pattern of behavioral deficits observed in GASP-1-deficient mice is coherent with current knowledge of the role of striatal G protein-coupled receptor(GPCR (show TAS1R3 Proteins))s in acquisition/expression of skilled behavior and motivation.
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.
G protein-coupled receptor associated sorting protein 1
, G-protein coupled receptor-associated sorting protein 1
, G-protein coupled receptor-associated sorting protein 1-like
, Per1 interacting protein
, per1-interacting protein