GDNF Family Receptor alpha 2 Proteins (GFRA2)

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. Additionally we are shipping GFRA2 Antibodies (74) and GFRA2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GFRA2 2675 O00451
Rat GFRA2 GFRA2 25136  
GFRA2 14586  
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Top GFRA2 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
$272.80
Details
HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$615.00
Details
Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$170.50
Details
Human Human His tag   10 μg Log in to see 15 to 16 Days
$125.00
Details
HEK-293 Cells Human His tag Human GFR alpha-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 200 μg Log in to see 2 to 3 Days
$308.00
Details
HEK-293 Cells Human Un-conjugated Validation with Western Blot 10 μg Log in to see 12 to 15 Days
$345.35
Details
HEK-293 Human His tag   0.2 mg Log in to see 2 to 3 Days
$550.00
Details

GFRA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
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Mouse (Murine) , ,
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More Proteins for GDNF Family Receptor alpha 2 (GFRA2) Interaction Partners

Human GDNF Family Receptor alpha 2 (GFRA2) interaction partners

  1. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET (show RET Proteins) tyrosine kinase (show TXK Proteins).

  2. High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance.

  3. GFRA2 variants associated with diabetic neuropathic pain.

  4. The study shows co-localization of RET (show RET Proteins) with GFRA1 (show GFRA1 Proteins) and GFRA2 in myenteric ganglia of the adult human colon.

  5. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms.

  6. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.

  7. This study found nominally-significant evidence for interactions between GFRA1 (show GFRA1 Proteins), 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.

  8. Both GFR (show RAPGEF5 Proteins) alpha2a and GFR (show RAPGEF5 Proteins) alpha2c, but not GFR (show RAPGEF5 Proteins) alpha2b (show ADRA2B Proteins), promote neurite outgrowth in transfected Neuro2A cells.

Mouse (Murine) GDNF Family Receptor alpha 2 (GFRA2) interaction partners

  1. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET (show RET Proteins) tyrosine kinase (show TYRO3 Proteins).

  2. Ret (show RET Proteins) and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.

  3. STAT3 (show STAT3 Proteins) phosphorylation by neurturin (show NRTN Proteins) was found to be mediated specifically by GFRalpha2c and RET9 (show RET Proteins) isoforms.

  4. Cholinergic innervation of gastric mucosa depends on neurturin (show NRTN Proteins)-GFRalpha2 signalling but is dispensable for gastrin (show GAST Proteins) secretion and for basal and maximal acid output

  5. our data demonstrate that RET (show RET Proteins)/GFRalpha signals are dispensable for thymic T cell development in vivo

  6. Transduction-function role for GFR (show RAPGEF5 Proteins) alpha2/neurturin (show NRTN Proteins) signalling in a specific class of sensory neurons.

  7. The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation.

  8. Demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon (show GCG Proteins)-like peptides to inhibit GI motility, but not in intestinal growth.

GFRA2 Protein Profile

Protein Summary

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GFRA2

  • DKFZP459C0228 protein (DKFZP459C0228)
  • GDNF family receptor alpha 2 (gfra2)
  • GDNF family receptor alpha 2a (gfra2a)
  • GDNF family receptor alpha 2 (GFRA2)
  • GDNF family receptor alpha 2 (Gfra2)
  • glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2)
  • DKFZP459C0228 protein
  • GDNFRB protein
  • gfra2 protein
  • NRTNR-ALPHA protein
  • NTNRA protein
  • NTNRALPHA protein
  • Retl2 protein
  • TRNR2 protein

Protein level used designations for GFRA2

DKFZP459C0228 protein , GFR-alpha-2 , GDNF family receptor alpha-2 , GDNF family receptor alpha 2 , glial cell line derived neurotrophic factor family receptor alpha 2 , GFR alpha 2 , GDNF family receptor alpha-2-like , GDNF receptor beta , GDNFR-alpha-2 , GDNFR-beta , GFR-alpha 2 , NTNR-alpha , PI-linked cell-surface accessory protein , RET ligand 2 , TGF-beta-related neurotrophic factor receptor 2 , TRN receptor, GPI-anchored , glial cell line derived neurotrophic factor receptor, beta , neurturin receptor alpha , GDNF receptor alpha-2 , tyrosine kinase receptor ligand 2 , NRTNR-alpha , GFR alpha-2

GENE ID SPECIES
100189713 Pongo abelii
100127717 Xenopus (Silurana) tropicalis
405794 Danio rerio
100475044 Ailuropoda melanoleuca
2675 Homo sapiens
609172 Canis lupus familiaris
514036 Bos taurus
25136 Rattus norvegicus
395993 Gallus gallus
100171804 Pongo abelii
14586 Mus musculus
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