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The protein encoded by GFRA3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. Additionally we are shipping GFRA3 Antibodies (95) and GFRA3 Kits (3) and many more products for this protein.
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increased GFRalpha3 expression is significantly correlated with poor prognosis of patients with urothelial carcinoma
Mir-34a directly regulates GFRA3 via its coding region.GFRA3 is crucial for breast cancer growth.
The GFRA3 promoter region showed marked hypermethylation in almost all tumors, and its correlation with survival and other clinicopathological parameters may have important prognostic significance.
The expression of GFRalpha1 and/or GFRalpha3, especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma.
The lack of expression of the RET/GFRA system could be related to the cell mislocation and deregulated growth of craniopharyngiomas.
This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.
Artemin and GFRalpha3 expressions may play an important role in perineural invasion of pancreatic carcinoma.
1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3 was reported.
In the human digestive and reproductive systems, a subset of epithelial cells exhibited GFRalpha3- and RET-like staining, suggesting co-localization.
GFRa3 is expressed at the surface of a subset of Ngn3-positive endocrine progenitors as well as of embryonic alpha- and beta-cells in the mouse pancreas.
cold allodynia is mediated exclusively by a single molecular pathway, suggesting that artemin-GFRalpha3 signaling can be targeted to selectively treat cold pain.
We found that artemin, the specific GFRalpha3 ligand that evokes heat hyperalgesia, robustly sensitized cold responses in a TRPM8-dependent manner in mice.
Suggest that enhanced GFRalpha3 signaling in visceral afferents may contribute to development of colorectal hypersensitivity.
GFRalpha3, the receptor for artemin, is increased following axotomy and regeneration in heat-sensitive C-fibers.
Data report an autocrine/paracrine role of the artemin-GFRA3 signaling system in regulating early embryonic development and apoptosis.
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.
GDNF family receptor alpha-3
, GDNF-family receptor alpha 3
, glial cell line derived neurotrophic factor family receptor alpha 3
, GDNF family receptor alpha 3
, GDNF family receptor alpha-3-like
, GDNF receptor alpha-3
, GPI-linked receptor
, glial cell line-derived neurotrophic factor receptor alpha-3
, GFR alpha-3