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This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15.
Showing 3 out of 4 products:
Yeast two-hybrid (Y2H) screens indicate 27 novel GRINL1A complex locus 1 (GCOM1) interacting genes, many of which are synaptic proteins and/or play roles in neurologic diseases.
Reveal myozap (show MYZAP Proteins) as a previously unrecognized component of a Rho-dependent signaling pathway that links the intercalated disc to cardiac gene regulation.
Assignment of GRINL1B, a glutamate (show GRIN1 Proteins) receptor-like processed gene, to human chromosome 4q12
Cardiac overexpression of Myozap (show MYZAP Proteins) results in cardiomyopathy with hypertrophy and left ventricular dilation.
This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternate splicing results in two readthrough transcript variants that encode different isoforms. One of the readthrough variants encodes a fusion protein that shares sequence identity with each individual gene product. The other variant encodes a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct due to frameshifts relative to the downstream gene.
GRINL1A combined protein
, GRINL1A combined protein Gcom12
, GRINL1A complex locus protein 1
, MYZAP-POLR2M protein
, MYZAP-POLR2M readthrough
, NMDAR1 subunit-interacting protein
, glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A combined protein
, myocardial zonula adherens protein