GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein Proteins (GRASP)

GRASP encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. Additionally we are shipping GRASP Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GRASP 56149 Q9JJA9
GRASP 160622 Q7Z6J2
GRASP 192254 Q8R4T5
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Top GRASP Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,749.58
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,089.17
Details

GRASP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

Rat (Rattus)

More Proteins for GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP) Interaction Partners

Mouse (Murine) GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP) interaction partners

  1. Study results indicate a potential role of Grasp in the p53-mediated response of skin to UVB exposure

  2. A major mechanism by which insulin regulates glut4 recycling was uncovered. A general receptor for 3-phosphoinositides 1 was identified as a guanine nucleotide exchange factor for ADP-ribosylation factor 6 that promotes glut4 vesicle formation.

  3. An upregulation of scaffold protein tamalin is found selectively in the hippocampus of animals subjected to electroconvulsive shock.

  4. Caspase cleavage of GRASP-1 occurs in specific brain regions in a time-dependent manner during development and ischemia.

  5. tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk signaling in an ITAM-based fashion

  6. plays a role in metabotropic glutamate receptor transport and forms its autoinhibitory state.[review]

Human GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP) interaction partners

  1. Schizophrenia subjects compared to controls showed a marked increase in CA1 hippocampal Norbin, and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 signalling and trafficking

  2. myristoylated GRASP promoted tethering and exhibited a unique membrane complex. Thus, myristoylation restricts the membrane orientation of the GRASP domain favoring interactions in trans for membrane tethering.

  3. GRASP bridges the guanine nucleotide exchange factors (GEFs) that activate Arf and Rac, thereby promoting Arf-to-Rac signaling By binding to both cytohesin 2/ARNO and Dock180.

  4. GRASP regulates the non-clathrin/Arf6-dependent, plasma membrane recycling and signalling pathways.

  5. the structural basis of the phosphoinhibition of GRASP-mediated membrane tethering and provide a mechanism for its allosteric regulation.

  6. protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF

  7. The crystal structures of the autoinhibitory PDZ domain of Tamalin has implications for the regulation of metabotropic glutamate receptor trafficking.

GRASP Protein Profile

Protein Summary

This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.

Gene names and symbols associated with GRASP

  • general receptor for phosphoinositides 1 associated scaffold protein (GRASP)
  • GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein (grasp)
  • GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein (Grasp)
  • general receptor for phosphoinositides 1 associated scaffold protein (Grasp)
  • GRASP protein
  • TAMALIN protein

Protein level used designations for GRASP

general receptor for phosphoinositides 1-associated scaffold protein , GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein , GRP1-associated scaffold protein , 95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein , Grp1 (general receptor for phosphoinositides)-associated scaffold protein , PSD-95 PDZ domain-containing protein , tamalin

GENE ID SPECIES
507181 Bos taurus
696547 Macaca mulatta
739673 Pan troglodytes
100145424 Xenopus (Silurana) tropicalis
56149 Mus musculus
160622 Homo sapiens
192254 Rattus norvegicus
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