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GRASP encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. Additionally we are shipping GRASP Antibodies (35) and many more products for this protein.
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Study results indicate a potential role of Grasp in the p53-mediated response of skin to UVB exposure
A major mechanism by which insulin regulates glut4 recycling was uncovered. A general receptor for 3-phosphoinositides 1 was identified as a guanine nucleotide exchange factor for ADP-ribosylation factor 6 that promotes glut4 vesicle formation.
An upregulation of scaffold protein tamalin is found selectively in the hippocampus of animals subjected to electroconvulsive shock.
Caspase cleavage of GRASP-1 occurs in specific brain regions in a time-dependent manner during development and ischemia.
tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk signaling in an ITAM-based fashion
plays a role in metabotropic glutamate receptor transport and forms its autoinhibitory state.[review]
Schizophrenia subjects compared to controls showed a marked increase in CA1 hippocampal Norbin, and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 signalling and trafficking
myristoylated GRASP promoted tethering and exhibited a unique membrane complex. Thus, myristoylation restricts the membrane orientation of the GRASP domain favoring interactions in trans for membrane tethering.
GRASP bridges the guanine nucleotide exchange factors (GEFs) that activate Arf and Rac, thereby promoting Arf-to-Rac signaling By binding to both cytohesin 2/ARNO and Dock180.
GRASP regulates the non-clathrin/Arf6-dependent, plasma membrane recycling and signalling pathways.
the structural basis of the phosphoinhibition of GRASP-mediated membrane tethering and provide a mechanism for its allosteric regulation.
protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF
The crystal structures of the autoinhibitory PDZ domain of Tamalin has implications for the regulation of metabotropic glutamate receptor trafficking.
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.
general receptor for phosphoinositides 1-associated scaffold protein
, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
, GRP1-associated scaffold protein
, 95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein
, Grp1 (general receptor for phosphoinositides)-associated scaffold protein
, PSD-95 PDZ domain-containing protein