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The protein encoded by GNPDA2 is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Additionally we are shipping Glucosamine-6-Phosphate Deaminase 2 Antibodies (33) and Glucosamine-6-Phosphate Deaminase 2 Kits (3) and many more products for this protein.
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GNPDA1 (show GNPDA1 Proteins) siRNA induced GFAT2 which was hardly measurable in these cells under standard culture conditions, GNPDA2 siRNA increased GFAT1 (show GFPT1 Proteins), and GFAT1 (show GFPT1 Proteins) siRNA increased the expression of hyaluronan synthase 2 (HAS2 (show HAS2 Proteins)). Silencing of GFAT1 (show GFPT1 Proteins) stimulated GNPDA1 (show GNPDA1 Proteins) and GDPDA2, and inhibited cell migration.
Data show that SNPs in SEC16B (show SEC16B Proteins) and TMEM18 (show TMM18 Proteins) were significantly associated with obesity, and the SNPs in GNPDA2, BDNF (show BDNF Proteins), FAIM2 (show FAIM2 Proteins) and MC4R (show MC4R Proteins) were marginally associated with obesity in Japanese.
The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
glcN6P deaminase 2
, glucosamine-6-phosphate isomerase 2
, glucosamine-6-phosphate isomerase SB52
, GNPDA 2