Glucose-6-Phosphate Isomerase Proteins (GPI)

GPI belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. Additionally we are shipping Glucose-6-Phosphate Isomerase Antibodies (251) and Glucose-6-Phosphate Isomerase Kits (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GPI 292804 Q6P6V0
GPI 14751 P06745
GPI 2821 P06744
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Top Glucose-6-Phosphate Isomerase Proteins at

Showing 10 out of 60 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 13 to 16 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
Yeast Calanus finmarchicus His tag   1 mg Log in to see 60 to 71 Days

GPI Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)
Human , ,
, , ,

More Proteins for Glucose-6-Phosphate Isomerase (GPI) Interaction Partners

Mouse (Murine) Glucose-6-Phosphate Isomerase (GPI) interaction partners

  1. PGI (show BGN Proteins) is a moonlighting protein that functions as a cytosolic enzyme involved in glycolysis and gluconeogenesis, and as cytokine through binding to its cell surface receptor.

  2. The mGPI-transgenic mice presented GPI more efficiently and showed a dramatic increase in negative selection and an inhibition of arthritis.

  3. Increased red cell turnover in a line of CD22 (show CD22 Proteins)-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.

  4. Data show that silencing of AMF/PGI induced MET and suppressed the tumor growth and pulmonary metastasis of LM8 cells in nude mice.

  5. induces hyperpermeability of endothelial and mesothelial cells leading to accumulation of ascites fluid (tumor autocrine motility factor)

  6. acid-induced conformational changes in phosphoglucose isomerase result in its increased cell surface association and deposition on fibronectin (show FN1 Proteins) fibrils

  7. Gpi1 (show PIGQ Proteins) immunoreactivity was found in ganglion, amacrine, horizontal and bipolar cells, but not in rods, cones, pigment epithelium and Muller cells.

  8. crystal structure of Autocrine Motility Factor

  9. AMF expression significantly contributes to the aggressive phenotype of pancreatic cancer

  10. Results report the first high-resolution crystal structure of the inhibitor-free form and the eight types of inhibitor complexes of mouse autocrine motility factor.

Human Glucose-6-Phosphate Isomerase (GPI) interaction partners

  1. Study demonstrated a novel pathway regulating hypoxia-induced angiogenesis in rheumatoid arthritis mediated by glucose-6-phosphate isomerase.

  2. Our data suggest that glucose-6-phosphate isomerase gene polymorphism may serve as potential biomarkers to predict the overall survival of hepatocellular carcinoma.

  3. Mutation p.Gln413Arg fs*24 is the first frameshift null mutation to be described in GPI (show GNPDA1 Proteins) deficiency. Molecular modeling suggests that the structural change induced by the p.Gly87Ala pathogenic variant has direct impact in the structural arrangement of the region close to the active site of the enzyme.

  4. The 2 cysteines in hGPIc-c are prone to form disulfides upon oxidation. hGPIc-c could induce arthritis in both B10 (show ENPP3 Proteins).Q and B10Q.Ncf1*/* mice, whereas hGPIs-s immunization did not induce disease at all, showing that these disulfides are critical for the arthritis-inducing immune response. The cysteines at position 330 and 333 are not crucial for TCR recognition. GILT (show IFI30 Proteins) expression affects hGPI-c-c processing at the CXXC motif.

  5. These results suggested that E4P by directly interacting with extracellular HPI/AMF may be an effective strategy to deter BCSC growth and progression.

  6. The silencing of PGI/AMF decreased the levels of phosphorylated Akt (show AKT1 Proteins) (-71.9%, P<0.001) compared with the scrambled siRNA, as well as the levels of the stemness marker, SOX2 (show SOX2 Proteins) (-61.7%, P<0.01). Taken together, these findings suggest that PGI/AMF silencing decreases migration, tumorsphere formation as well as the proportion of on the side population cells in glioblastoma U87 cells.

  7. NLK (show NLK Proteins) is able to promote cell proliferation and type II collagen (show COL2A1 Proteins) synthesis during in vitro chondrocyte propagation.

  8. Suggest tha AMF/PGI-mediated tumorigenesis occurs through MAPK-ERK (show MAPK1 Proteins) signaling in endometrial carcinoma.

  9. Study supports a role for AMF mediating epithelial-mesenchymal transition in endometrial cancer (EC) through MAPK (show MAPK1 Proteins) signaling. Therefore, AMF may provide a potential prognostic and therapeutic target in preventing EC progression.

  10. Results showed an increase in GPI (show GNPDA1 Proteins) and AMFR (show AMFR Proteins) in clear cell-renal cell carcinoma (show MOK Proteins) cells, and their colocalization on plasma membrane. Kaplan-Meier curves showed significant differences in survival among groups of patients with high versus low GPI (show GNPDA1 Proteins).

Zebrafish Glucose-6-Phosphate Isomerase (GPI) interaction partners

  1. The differential expression of gpia (show ITGA2 Proteins) and gpib in zebrafish suggests partition or divergence of gpi (show ITGA2 Proteins) functions between the two duplicates.

  2. Comparison of glucose phosphase isomerase (GPI (show ITGA2 Proteins)) genes from several vertebrates suggests that GPIs are being subjected to purifying selection to maintain the polarity and volume of the protein, but not its charge.

Glucose-6-Phosphate Isomerase (GPI) Protein Profile

Protein Summary

This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

Gene names and symbols associated with GPI

  • glucose-6-phosphate isomerase (GPI)
  • glucose-6-phosphate isomerase (Gpi)
  • glucose-6-phosphate isomerase (gpi)
  • gpi (pgi)
  • glucose-6-phosphate isomerase 1 (GPI1)
  • gpi Glucose-6-phosphate isomerase (gpi)
  • Phosphoglucose isomerase (Pgi)
  • glucose phosphate isomerase 1 (Gpi1)
  • glucose-6-phosphate isomerase b (gpib)
  • AMF protein
  • CG8251 protein
  • DDBDRAFT_0185620 protein
  • DDBDRAFT_0231026 protein
  • DDB_0185620 protein
  • DDB_0231026 protein
  • Dmel\\CG8251 protein
  • GNPI protein
  • gpi protein
  • Gpi-1 protein
  • Gpi-1r protein
  • Gpi-1s protein
  • Gpi-1t protein
  • Gpi1 protein
  • Gpi1-r protein
  • Gpi1-s protein
  • Gpi1-t protein
  • Gpi1s protein
  • MF protein
  • NK protein
  • NK/GPI protein
  • NLK protein
  • Org protein
  • pgi protein
  • pgi-2 protein
  • PHI protein
  • SA-36 protein
  • SA36 protein

Protein level used designations for GPI

AMF , NLK , PHI , autocrine motility factor , glucose phosphate isomerase , muscle phosphohexose isomerase , neuroleukin , phosphoglucose isomerase , phosphohexose isomerase , PGI , glucosephosphate isomerase , glucose-6-phosphate isomerase , gpi Glucose-6-phosphate isomerase , CG8251-PA , CG8251-PB , CG8251-PC , Pgi-PA , Pgi-PB , Pgi-PC , phosphoglucoisomerase , glucose phosphate isomerase 1 complex , glucose phosphate isomerase 1, regulatory , glucose phosphate isomerase 1, structural , glucose phosphate isomerase 1, temporal , maturation factor , structural glucose phosphate isomerase 1 , hexose monophosphate isomerase , hexosephosphate isomerase , oxoisomerase , phosphohexomutase , phosphosaccharomutase , sperm antigen 36 , sperm antigen-36 , glucose phosphate isomerase b

397602 Sus scrofa
280808 Bos taurus
292804 Rattus norvegicus
415783 Gallus gallus
100174006 Pongo abelii
3116331 Legionella pneumophila str. Lens
692243 Hordeum vulgare
3117706 Legionella pneumophila str. Paris
1022330 Bifidobacterium longum NCC2705
7997113 Bartonella grahamii as4aup
543945 Solanum lycopersicum
780596 Triticum aestivum
1089499 Tropheryma whipplei str. Twist
8624197 Dictyostelium discoideum AX4
8691155 Bifidobacterium dentium Bd1
100008744 Oryctolagus cuniculus
35886 Drosophila melanogaster
611942 Canis lupus familiaris
14751 Mus musculus
2821 Homo sapiens
100057160 Equus caballus
100719769 Cavia porcellus
246095 Danio rerio
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