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Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Additionally we are shipping GANAB Antibodies (56) and GANAB Kits (1) and many more products for this protein.
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used whole exome sequencing in a discovery cohort of 102 unrelated patients who were excluded for mutations in the 2 most common polycystic liver disease genes, PRKCSH (show PRKCSH Proteins) and SEC63 (show SEC63 Proteins), to identify heterozygous loss-of-function mutations in 3 additional genes, ALG8 (show ALG8 Proteins), GANAB, and SEC61B (show SEC61B Proteins). Similarly to PRKCSH (show PRKCSH Proteins) and SEC63 (show SEC63 Proteins), these genes encode proteins that are integral to the protein biogenesis pathway in the endoplasmic reticulum.
Mutations in GANAB gene is associated with Autosomal-Dominant Polycystic Kidney and Liver Disease.
Loss of the tumor suppression function of Hsp60 (show HSPD1 Proteins) or GANAB contribute to aggressive cancers.
In males being treated for infertility, neutral alpha-glucosidase (show AGLU Proteins) activity correlated with the percentage of sperm DNA fragmentation.
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.
alpha glucosidase II alpha subunit
, neutral alpha-glucosidase AB
, glucosidase, alpha; neutral AB
, neutral alpha-glucosidase AB-like
, alpha-glucosidase 2
, carbohydrate processing enzyme of the endoplasmic reticulum
, glucosidase II alpha-subunit
, glucosidase II subunit alpha
, alpha glucosidase 2 alpha neutral subunit
, neutral AB