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QPCT encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. Additionally we are shipping QPCT Antibodies (60) and QPCT Kits (13) and many more products for this protein.
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Human QPCT Protein expressed in Baculovirus infected Insect Cells - ABIN2005890
Bateman, Temple, Misquitta, Booth: Evidence for essential histidines in human pituitary glutaminyl cyclase. in Biochemistry 2001
Show all 3 Pubmed References
the genetic risk of QPCT gene for schizophrenia also exists in the Han Chinese population.
observations provide evidence for an involvement of QC in Alzheimer's disease pathogenesis and cognitive decline by QC-catalyzed pGlu-Abeta (show APP Proteins) formation
this study demonistrated that QPCT mRNAand protein from mononuclear cells correlated with theseverity of dementia.
Upregulation of QPCT expression is associated with thyroid carcinomas.
The resilts of this studt provided histopathological evidence for QC being a prerequisite for pE-Abeta (show APP Proteins) pathology in vivo and further underline the therapeutic potential of QC inhibition in Alzheimer Disease.
Upon binding to PBD150, a large loop movement in gQC (show QPCTL Proteins) allows the inhibitor to be tightly held in its active site primarily by hydrophobic interactions.
This study demonstrated that glutaminyl cyclase expression and pE-Abeta (show APP Proteins) formation in subcortical brain regions( Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert) affected in Alzheimer's disease.
Human isoQC (show QPCTL Proteins)proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
Functional expression of human glutaminyl cyclase in Pichia pastoris reveals the presence of a disulfide bond with an important role in the stabilization of active protein structure.
human glutaminyl cyclase is a metal-dependent transferase
Authors identified a placenta-specific imprinted gene Qpct. Results show that Qpct is widely expressed during early embryonic development and can be detected in the telencephalon, midbrain, and rhombencephalon at E9.5-E11.5.
co-regulation of the enzyme glutaminyl cyclase and its substrate TRH (show TRH Proteins) was reflected by a co-induction of both proteins in reactive astrocytes in proximity of Abeta (show APP Proteins) deposits
This study provide a thorough comparative characterization of the glutaminyl cyclases QC and isoQC (show QPCTL Proteins) in defined brain regions of different inbred and outbred mouse strains
Glutaminyl cyclase in a mouse knockout model has a role in hypothyroidism but not hypogonadism
Murine isoQC (show QPCTL Proteins) proteins displayed a broad substrate specificity and preference for hydrophobic substrates, similar to the related QC.
Results describe the expression of glutaminyl cyclase throughout the mouse brain during early postnatal development.
The observations of this study indicated that brain ischemia might be a pathogenic factor of alzheimer disease through increasing BACE1 (show BACE Proteins), cathepsin B (show CTSB Proteins), and glutaminyl cyclase.
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
, glutaminyl cyclase
, glutaminyl-tRNA cyclotransferase
, glutamyl cyclase
, glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
, glutaminyl-peptide cyclotransferase
, glutaminyl-peptide cyclotransferase-like 1
, glutaminyl-peptide cyclotransferase L homeolog