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Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
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GSTP1 (show GSTP1 Proteins)/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.
Matrin 3 (show MATR3 Proteins) interacts specifically with the heat shock proteins glucose-regulated protein 78 (show HSPA5 Proteins), GRP75 (show HSPA9 Proteins) and glutathione S-transferase (show GSTa2 Proteins) pi isoform 2.
Apc (show APC Proteins)(Min/+)Gstp1 (show GSTP1 Proteins)/p2(-/-) (Gstp (show GSTP1 Proteins)-null Apc (show APC Proteins)(Min)) mice had a 6-fold increase in colon adenoma incidence, and a 50-fold increase in colorectal adenoma multiplicity, relative to Gstp (show GSTP1 Proteins)-wt Apc (show APC Proteins)(Min).
Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells.
role as a direct inhibitor of JNK (show MAPK8 Proteins) in vivo and in regulating the constitutive expression of specific downstream molecular targets of the JNK (show MAPK8 Proteins) signaling pathway
The glutathione S-transferase (show GSTa2 Proteins), pi 2 (show SERPINB1 Proteins) was represented by two EST (show MAP3K8 Proteins) clones with similar levels of downregulation.
The downregulation of Gstp2 (show GSTP1 Proteins) may induce an increase of oxidative damage in the pyramidal cells of the CA1 (show CA1 Proteins) and CA3 (show CA3 Proteins) regions and granular layer of the dentate gyrus, leading to structural and functional damage.
GSTP (show GSTP1 Proteins) protects against the endothelial dysfunction induced by tobacco smoke exposure and that this protection may be related to the detoxification of acrolein or other related cigarette smoke constituents.
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene.
, GST class-pi
, Gst p-2
, glutathione S-transferase P 2
, gst P2