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Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Additionally we are shipping Glycine Dehydrogenase Antibodies (70) and Glycine Dehydrogenase Kits (26) and many more products for this protein.
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Exencephaly and ventriculomegaly were detectable by High-frequency ultrasound in homozygous Gldc-deficient mouse embryos indicating this to be an effective tool to study CNS development.
These studies support a direct relationship between p53 (show TP53 Proteins) mutations and GLDC expression in B cell lymphoma.
Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice through limiting supply of one-carbon units from mitochondrial folate metabolism.
Results suggest that there is a direct correlation between ischemic injury and extracellular glycine concentration maintained by glycine decarboxylase and the glycine cleavage multienzyme system.
a comprehensive functional and structural analysis of 19 GLDC missense variants identified in a cohort of 26 nonketotic hyperglycinemia patients was performed
The position and frequency of the breakpoint for CNVs correlated with intron size and presence of Alu elements. Missense mutations, most often recurring, were the most common type of disease-causing mutation in AMT (show AMT Proteins)
We show that the combination of GLDC and HIF-1alpha (show HIF1A Proteins) expression is an independent prognostic factor in early-stage lung non-small cell cancer
Data indicate no mutation was found in glycine cleavage system protein-H (show GCSH Proteins) (GCSH (show GCSH Proteins)) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT (show AMT Proteins)) are the main cause of glycine encephalopathy in Malaysian population.
study reports a novel mutation, c.2296G>T (p.Gly766Cys), in exon 19 of the glycine decarboxylase (GLDC) gene in a consanguineous Indian couple with a history of 4 neonatal deaths
Identification of a splice acceptor site mutation and five different non-synonymous variants in GLDC were found in patients with neural tube defects.
Study shows that glycine metabolism and the metabolic enzyme glycine decarboxylase (GLDC) drive tumor-initiating cells and tumorigenesis in non-small cell lung cancer.
Heterozygous GLDC gene mutation in transient neonatal hyperglycinemia.
Three adults with mild hyperglycinemia, infantile hypotonia, mental retardation, behavioral hyperirritability, and aggressive outbursts were screened for glycine decarboxylase mutations; two novel missense mutations were found.
The mutation in this nonketotic hyperglycinemia kindred led to missplicing and reduced GLDC (glycine decarboxylase) expression.
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
, glycine cleavage system P protein
, glycine dehydrogenase [decarboxylating], mitochondrial
, glycine cleavage system protein P
, glycine decarboxylase P-protein
, glycine cleavage system protein P)
, glycine decarboxylase
, glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P)
, glycine decarboxylase, glycine cleavage system protein P)
, glycine dehydrogenase (decarboxylating), mitochondrial
, glycine decarboxylase S homeolog
, glycine dehydrogenase (decarboxylating) S homeolog