Glycine Dehydrogenase Proteins (GLDC)

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). Additionally we are shipping Glycine Dehydrogenase Antibodies (63) and Glycine Dehydrogenase Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GLDC 104174 Q91W43
GLDC 2731 P23378
Rat GLDC GLDC 309312  
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Top Glycine Dehydrogenase Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process GBA3 dissolution curves 1 mg Log in to see 70 Days
$11,073.30
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$858.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$704.00
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Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$1,058.75
Details

GLDC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
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Human , ,
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More Proteins for Glycine Dehydrogenase (GLDC) Interaction Partners

Mouse (Murine) Glycine Dehydrogenase (GLDC) interaction partners

  1. Exencephaly and ventriculomegaly were detectable by High-frequency ultrasound in homozygous Gldc-deficient mouse embryos indicating this to be an effective tool to study CNS development.

  2. These studies support a direct relationship between p53 (show TP53 Proteins) mutations and GLDC expression in B cell lymphoma.

  3. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice through limiting supply of one-carbon units from mitochondrial folate metabolism.

  4. Results suggest that there is a direct correlation between ischemic injury and extracellular glycine concentration maintained by glycine decarboxylase and the glycine cleavage multienzyme system.

Human Glycine Dehydrogenase (GLDC) interaction partners

  1. We show that the combination of GLDC and HIF-1alpha (show HIF1A Proteins) expression is an independent prognostic factor in early-stage lung non-small cell cancer

  2. Data indicate no mutation was found in glycine cleavage system protein-H (show GCSH Proteins) (GCSH (show GCSH Proteins)) and suggest that mutations in both glycine decarboxylase (GLDC) and aminomethyltransferase (AMT (show AMT Proteins)) are the main cause of glycine encephalopathy in Malaysian population.

  3. study reports a novel mutation, c.2296G>T (p.Gly766Cys), in exon 19 of the glycine decarboxylase (GLDC) gene in a consanguineous Indian couple with a history of 4 neonatal deaths

  4. Identification of a splice acceptor site mutation and five different non-synonymous variants in GLDC were found in patients with neural tube defects.

  5. Study shows that glycine metabolism and the metabolic enzyme glycine decarboxylase (GLDC) drive tumor-initiating cells and tumorigenesis in non-small cell lung cancer.

  6. Heterozygous GLDC gene mutation in transient neonatal hyperglycinemia.

  7. Three adults with mild hyperglycinemia, infantile hypotonia, mental retardation, behavioral hyperirritability, and aggressive outbursts were screened for glycine decarboxylase mutations; two novel missense mutations were found.

  8. The mutation in this nonketotic hyperglycinemia kindred led to missplicing and reduced GLDC (glycine decarboxylase) expression.

  9. Single nucleotide substitution that abolishes the initiator methionine codon of the GLDC gene is associated with glycine encephalopathy

  10. the nonketotic hyperglycinemia is due to a novel GLDC mutation.

Glycine Dehydrogenase (GLDC) Protein Profile

Protein Summary

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

Gene names and symbols associated with Glycine Dehydrogenase Proteins (GLDC)

  • glycine dehydrogenase (decarboxylating) GcvP (gcvP)
  • glycine dehydrogenase (gcvP)
  • glycine dehydrogenase (Tb927.7.1910)
  • glycine cleavage system P-protein (gcvP)
  • glycine decarboxylase (Gldc)
  • glycine decarboxylase (GLDC)
  • glycine dehydrogenase (decarboxylating) (gldc)
  • glycine decarboxylase S homeolog (gldc.S)
  • D030049L12Rik protein
  • D19Wsu57e protein
  • DDBDRAFT_0219205 protein
  • DDBDRAFT_0231130 protein
  • DDB_0219205 protein
  • DDB_0231130 protein
  • fb23b05 protein
  • GCE protein
  • GCSP protein
  • gldc protein
  • HYGN1 protein
  • PSPTO1276 protein
  • Tb07.43M14.350 protein
  • wu:fb23b05 protein
  • zgc:66198 protein

Protein level used designations for Glycine Dehydrogenase Proteins (GLDC)

glycine dehydrogenase , glycine cleavage system P protein , glycine dehydrogenase [decarboxylating], mitochondrial , glycine cleavage system protein P , glycine decarboxylase P-protein , glycine cleavage system protein P) , glycine decarboxylase , glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) , glycine decarboxylase, glycine cleavage system protein P) , glycine dehydrogenase (decarboxylating), mitochondrial , glycine decarboxylase S homeolog , glycine dehydrogenase (decarboxylating) S homeolog

GENE ID SPECIES
1168636 Shewanella oneidensis MR-1
1182912 Pseudomonas syringae pv. tomato str. DC3000
3196586 Ruegeria pomeroyi DSS-3
3658401 Trypanosoma brucei brucei strain 927/4 GUTat10.1
8626028 Dictyostelium discoideum AX4
104174 Mus musculus
2731 Homo sapiens
374222 Gallus gallus
309312 Rattus norvegicus
481534 Canis lupus familiaris
321621 Danio rerio
379833 Xenopus laevis
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