anti-Glycine Receptor (GRD) Antibodies

GRD encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits.

list all antibodies Gene Name GeneID UniProt
GRD 2743 P48167
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Top anti-Glycine Receptor Antibodies at

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Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Rat Rabbit Un-conjugated IHC, WB Western Blot of Anti-Glycine Receptor (Rabbit) Antibody - 600-401-D65 Western Blot of Rabbit anti-Glycine Receptor antibody. Lane 1: rat spinal cord. Lane 2: rat hippocampal. Load: 10 µg per lane. Primary antibody: Glycine receptor antibody at 1:400 for overnight at 4°C. Secondary antibody: rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: ~48kDa α1- and α2-subunits of the glycine receptor. Other band(s): none. 200 μg 1 to 2 Days
Human Goat Un-conjugated ELISA, WB Western blot testing of mouse testis lysate with Glycine receptor antibody at 0.3ug/ml. Predicted molecular weight ~48/60kDa (unmodified/glycosylated). 100 μg 2 to 3 Days
Human Rabbit Un-conjugated ICC, IHC, IHC (p), WB   50 μg 5 to 6 Days

More Antibodies against Glycine Receptor Interaction Partners

Human Glycine Receptor (GRD) interaction partners

  1. The association between the missense SNP rs2235371 in gene IRF6 and NSCL/P suggests that this SNP may play an important role as a risk factor for NSCL/P in the Han Chinese populations.

  2. Using quantitative photoactivated localisation microscopy the authors found that alpha-1 and alpha-3 containing glycine receptors display the same alpha3:beta2 stoichiometry and gephyrin binding.

  3. GLRB variants are associated with etiopathogenesis of fear and anxiety disorders.

  4. A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P = 3.3 x 10 - 8; rs191260602, P = 3.9 x 10- 8).GLRB gene expression was found to be modulated by rs7688285 in brain tissue, as well as cell culture.

  5. Whole-exome sequencing in ASD patients from each family identified a second rare inherited genetic variant, affecting GLRB expressed in inhibitory or in excitatory synapses.

  6. GLRA1 and GLRB mutations are responsible for abnormal startled reactions in humans. (Review)

  7. The N-terminal region of GABRA3 and the GlyR beta subunit occupies the same binding site of gephyrin.

  8. We report novel GLRB mutations in hyperekplexia

  9. p.E375X truncated subunits are incorporated into functional hGlyRs together with unmutated alpha1 or alpha1 plus beta subunits.

  10. Systematic DNA sequencing of GLRB in individuals with hyperekplexia revealed new missense mutations in GLRB, resulting in M177R, L285R and W310C substitutions.

  11. This study describes the definitive assignment of GLRB as the third major gene for hyperekplexia and impacts on the genetic stratification and biological causation of this neonatal/paediatric disorder.

  12. investigated neural progenitor cells in respect to their glycine receptor function and subunit expression using electrophysiology, calcium imaging, immunocytochemistry, and quantitative real-time PCR

  13. Distinct properties of glycine receptor beta+/alpha- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric protein.

  14. This study presents a large family with Hereditary hyperekplexia (HH) as a result of homozygous mutation in GLRB.

  15. Hereditary hyperekplexia-causing mutations that modify alpha1 beta GlyR channel function are almost exclusively located in the alpha1 to the exclusion of the beta subunit.

  16. The authors have identified a protein kinase C (PKC) phosphorylation site within the cytoplasmic domain of the beta-subunit of the GlyR (residue S403) that causes a reduction of the binding affinity between the receptor and gephyrin.

  17. proton modulation of glycine receptor function is determined by extracellular domain in both the alpha1 and beta subunits

  18. Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation

  19. Report interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study.

Glycine Receptor (GRD) Antigen Profile

Protein Summary

This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Glycine Receptor (GRD) Antibodies

  • glycine receptor beta (GLRB) antibody
  • HKPX2 antibody

Protein level used designations for anti-Glycine Receptor (GRD) Antibodies

glycine receptor 58 kDa subunit , glycine receptor subunit beta , glycine receptor, beta subunit

2743 Homo sapiens
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