Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) ELISA Kits

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. Additionally we are shipping Glycoprotein Ib (Platelet), alpha Polypeptide Antibodies (205) and Glycoprotein Ib (Platelet), alpha Polypeptide Proteins (15) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
GP1BA 2811  
Anti-Rat GP1BA GP1BA 691992  
GP1BA 14723 O35930
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Top Glycoprotein Ib (Platelet), alpha Polypeptide ELISA Kits at antibodies-online.com

Showing 8 out of 20 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 11.72 pg/mL 46.88-3000 pg/mL Typical standard curve 96 Tests 15 to 18 Days
$910.56
Details
Dog 0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests 15 to 18 Days
$1,026.67
Details
Human 0.35 ng/mL 0.78 ng/mL - 50 ng/mL 96 Tests 13 to 16 Days
$700.00
Details
Human 0.35 ng/mL 0.781 ng/mL - 50 ng/mL   96 Tests 8 to 12 Days
$928.46
Details
Chicken 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
$760.42
Details
Rabbit 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests 11 to 18 Days
$760.42
Details
Monkey 1.875 ng/mL 3.125 ng/mL - 200 ng/mL   96 Tests 11 to 18 Days
$760.42
Details
Pig 1.875 ng/mL 3.125 ng/mL - 200 ng/mL   96 Tests 11 to 18 Days
$760.42
Details

More ELISA Kits for Glycoprotein Ib (Platelet), alpha Polypeptide Interaction Partners

Human Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. A new heterozygous mutation in GP1BA gene responsible for macrothrombocytopenia.

  2. In GPIbalpha-deficient human Bernard-Soulier syndrome patients, a decrease occurred in circulating TPO.

  3. An autosomal dominant mode of inheritance, a family history of mild bleeding episodes, aggregation pattern in affected individuals together with evidence of mutation occurring in part of the GP1BA gene encoding the leucine-rich repeat region suggest a novel variant causing monoallelic Bernard-Soulier syndrome.

  4. Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2

  5. A review of mutations associated with Bernard-Soulier Syndrome and platelet type von Willebrand disease (review).

  6. ERK5 associates with CKII to play essential roles in GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway.

  7. There was no evidence to suggest that polymorphisms of GP VI T13254C and GP Ibalpha VNTR were associated with CAD.

  8. analysis of an artificial botrocetin that can inhibit the VWF-GPIb interaction

  9. Loss of the platelet surface receptors GPIbalpha and GPVI in heart failure, CF-VAD and ECMO patients may contribute to ablated platelet adhesion/activation, and limit thrombus formation under high/pathologic shear conditions

  10. Very low birth weight preterm neonates have increased numbers of platelets interacting with von Willebrand Factor, and increased GPIbalpha expression on the platelet surface

  11. Data suggest that an aspartate at position 1261 is the most critical residue of VWF N-terminal linker for inhibiting binding of VWF A1 domain to GP1BA on platelets in a model simulating blood flow velocity; network of salt bridges between Asp1261 and rest of VWF A1 domain lock N-terminal linker in place such that binding to GP1BA is reduced.

  12. Data show that von Willebrand factor (VWF) is first converted from a compact to linear form by flow, and is subsequently activated to bind platelet glycoprotein Ib alpha polypeptide (GPIbalpha) in a tension-dependent manner.

  13. The >30 nm macroglycopeptide separating the two domains of GPIbalpha transmits force on the VWF-GPIbalpha bond (whose lifetime is prolonged by leucine-rich repeat domain unfolding) to the juxtamembrane mechanosensitive domain to enhance its unfolding, resulting in unfolding cooperativity at an optimal force.

  14. Meta-analysis found that glycoprotein Ia C807T T allele or the TT genotype, the Ser-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke.

  15. Our results suggest that the -5CC genotype in Kozak sequence of GPIb-alpha may be associated with a higher risk of developing arterial ischemia of lower limbs in type 2 diabetes mellitus patients.

  16. Specific inhibition of GPIbalpha shedding in the stored platelets improves post-transfusion platelet recovery and hemostatic function, providing clear evidence for GPIbalpha shedding as a cause of platelet clearance.

  17. miR-10a and miR10b regulate the expression of human platelet GP1BA and GP1bb for normal megakaryopoiesis.

  18. Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF) or type I collagen under shear stresses.

  19. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin

  20. Lateral dimerization of GPIbalpha induced by antibody binding is not sufficient to initiate GPIb-IX signaling and induce platelet clearance.

Cow (Bovine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound

Mouse (Murine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) interaction partners

  1. A 2- to 3-fold decrease occurred in circulating TPO in GPIbalpha(-/-) mice compared with wild-type. Lower TPO levels in GPIbalpha-/- mice are due to impaired platelet-stimulated hepatic TPO production. The N terminus of GPIbalpha is required for platelet-mediated hepatic TPO generation.

  2. leukocyte Mac-1 and platelet GPIbalpha are involved in thrombosis

  3. GPIbbeta has a repressor function in thrombus formation

  4. this study shows that atheroma formation is inhibited in GPIba-deficient mice on atherosclerosis-prone background

  5. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin

  6. Thrombin cleavage of platelet PAR4 promotes leukocyte recruitment to sites of vascular injury. This process is negatively regulated by GPIbalpha.

  7. GPIbalpha-mediated interactions between platelets and endothelial cells, as well as leukocytes, support innate immune cell recruitment and promote arteriogenesis-establishing platelets as critical players in this process.

  8. Atherosclerosis reduction in mice lacking GPIbalpha may not result from the defective GPIbalpha-ligand binding, but more likely is a consequence of functional defects of GPIbalpha-/- platelets and reduced blood platelet counts.

  9. Data suggest that targeting platelet receptor glycoprotein Ibalpha (GPIbalpha)-von Willebrand factor VWF-A1 binding interface may offer a therapeutic approach to reducing platelet-driven thrombosis.

  10. Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GPIbalpha-VWF interactions.

  11. These data indicate an important role for the platelet adhesion receptor GPIb-IX in endotoxin-induced thrombosis and thrombocytopenia.

  12. Platelet IKKbeta deficiency increases the formation of injury-induced arterial neointimal tissue via delayed glycoprotein Ibalpha shedding.

  13. these data demonstrate that coordinated expression of GPIbalpha and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.

  14. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV for MP-dependent cleavage.

  15. miscarriage occurred in the majority of pregnancies in a model of anti-GPIbalpha-mediated fetal and neonatal immune thrombocytopenia (FNIT), which was far more frequent than in anti-integrinbeta3-mediated FNIT

  16. Data show that the surface-bound VWF appears as a large, linear structure on the surface of 50% of the PT-VWD platelets.

  17. Molecular models of the seven leucine-rich repeats of human and mouse GPIb alpha show 68% sequence homology, with no insertions or deletions in the repeat.

  18. Expression of the IL-4Ralpha/Gp1ba fusion sequence in a murine Bernard-Soulier syndrome model led to a 2-fold increase in platelet count and a 50% reduction in platelet size, confirming a critical role for the Gp1ba extracytoplasmic domain in hemostasis.

  19. the GP Ibalpha cytoplasmic tail sequestered signaling proteins during megakaryocytopoiesis

  20. GPIbalpha and GPV are shed through an ADAM17-dependent mechanism after aspirin administration

Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Antigen Profile

Antigen Summary

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Gene names and symbols associated with GP1BA

  • glycoprotein Ib platelet alpha subunit (GP1BA) antibody
  • glycoprotein Ib (platelet), alpha polypeptide (GP1BA) antibody
  • glycoprotein Ib platelet alpha subunit (Gp1ba) antibody
  • glycoprotein 1b, alpha polypeptide (Gp1ba) antibody
  • BDPLT1 antibody
  • BDPLT3 antibody
  • BSS antibody
  • CD42B antibody
  • CD42b-alpha antibody
  • DBPLT3 antibody
  • GP1B antibody
  • GP1BA antibody
  • GPIba antibody
  • GPIbalpha antibody
  • VWDP antibody

Protein level used designations for GP1BA

GP-Ib alpha , antigen CD42b-alpha , platelet glycoprotein Ib alpha chain , platelet membrane glycoprotein 1b-alpha subunit , glycoprotein Ib (platelet), alpha polypeptide , platelet glycoprotein Ib alpha polypeptide , GPIb-alpha , GPIbA , glycoprotein Ibalpha , glycoprotein 1b, alpha polypeptide , platelet glycoprotein Ib alpha chain-like

GENE ID SPECIES
2811 Homo sapiens
504977 Bos taurus
468166 Pan troglodytes
403638 Canis lupus familiaris
420059 Gallus gallus
691992 Rattus norvegicus
14723 Mus musculus
100717535 Cavia porcellus
100857333 Gallus gallus
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