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GPM6A encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. Additionally we are shipping Glycoprotein M6A Antibodies (101) and Glycoprotein M6A Kits (4) and many more products for this protein.
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HDAC5 (show HDAC5 Proteins) emerges as a cellular conductor of MEF2C (show MEF2C Proteins) and M6a activity and is regulated by miR (show MLXIP Proteins)-124 and miR (show MLXIP Proteins)-9 to control neurite development.
findings thus indicate a critical role of correct GPM6A/M6 levels for cognitive function and support a role of the GPM6A duplication for the patient's phenotype
Data indicate that neuronal membrane glycoproteins GPM6A and GPM6B (show GPM6B Proteins) may act as novel oncogenes in the development of lymphoid leukemia.
loosing dynamic regulation of neuronal GPM6A expression poses a genetic risk for claustrophobia
Results indicate that M6a modulates mu-opioid receptor (show OPRM1 Proteins) endocytosis and post-endocytotic sorting and has an important role in receptor regulation.
Results suggest that expression level of GPM6A is associated with the differentiation and neuronal migration of neurons derived from undifferentiated human embryonic stem cells.
GPM6a induces the clustering of lipid rafts and acts as a signal transducer that responds to extracellular signals.
This study demonistrated that M6a is essential for the support of neurite extension in developmental brain.
analysis of actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a
M6a-deficient axons grow actively but are not growth suppressed by antibodies bound to four-transmembrane actin-based glycoprotein M6a concentrated on the edge of the axon growth cone.
expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b (show LMX1B Proteins), En1 (show EN1 Proteins), Pax2, Pax5 (show PAX5 Proteins), Sox1 (show SOX1 Proteins), Sox2 (show SOX2 Proteins), and Wnt1 (show WNT1 Proteins)), and also the number of neural stem cells (NSC) derived from D3mshM6A cells
These results suggest that M6a plays a role in retinal development by regulating neurites, and it may also function to modulate synaptic activities in the adult retina.
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
neuronal membrane glycoprotein M6-a
, neuronal proteolipid GPM6A
, glycoprotein M6A
, glycoprotein M6A L homeolog
, glycoprotein M6A, myelin PLP-related membrane protein DM beta