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Has a beta-galactosyltransferase activity\; transfers beta-galactose to hydroxylysine residues of collagen (By similarity). Additionally we are shipping GLT25D1 Antibodies (18) and and many more products for this protein.
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GLT25D1 regulates HMW adiponectin secretion.
Loss of GLT25D1 led to increased expression and intracellular accumulation of collagen type I, whereas loss of GLT25D2 had no effect on collagen secretion. Inactivation of the GLT25D1 gene resulted in a compensatory induction of GLT25D2 expression.
introduced substitution Q471R-V472M-N473Q-P474V in the CEECAM1-C-terminal construct, which is found in most animal GLT25D1 and GLT25D2 isoforms but not in CEECAM1. This substitution was shown to partially restore collagen galactosyltransferase activity
Data indicate that galactosylation of collagenous proteins by the soluble GLT25D1 occurs in the early secretory pathway
Two collagen beta(1-O)galactosyltransferases corresponding to the GLT25D1 and GLT25D2 proteins were identified.
The downregulation of Glt25d1 deteriorated CCl4induced liver injury in mice, which may involve triggering inflammatory responses, apoptosis and TGFbeta1/Smad2 signaling pathway activation.
Has a beta-galactosyltransferase activity\; transfers beta-galactose to hydroxylysine residues of collagen (By similarity).
glycosyltransferase 25 domain containing 1
, glycosyltransferase 25 family member 1
, hydroxylysine galactosyltransferase 1
, procollagen galactosyltransferase 1
, collagen beta(1-O)galactosyltransferase 1