Gonadotropin-Releasing Hormone Receptor Proteins (GNRHR)

GNRHR encodes the receptor for type 1 gonadotropin-releasing hormone. Additionally we are shipping GNRHR Antibodies (120) and GNRHR Kits (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
GNRHR 2798 P30968
GNRHR 14715 Q01776
GNRHR 81668 P30969
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Top GNRHR Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,262.31
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,493.38
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Wheat germ Human Un-conjugated   10 μg Log in to see 11 to 12 Days
$564.00
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Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
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GNRHR Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

Rat (Rattus)

More Proteins for Gonadotropin-Releasing Hormone Receptor (GNRHR) Interaction Partners

Human Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. GnRHR triggers intracellular signaling pathways that acts through ARHGAP18.

  2. Data, including identification of GnRH/GnRH-receptor system in both ovary and endometrium, suggest that the spectrum of action of GnRH/GnRH-receptor system extends outside its well-known hypothalamic functions. [REVIEW]

  3. c.364C>T in GNRHR is a complete loss-of-function mutation which caused idiopathic hypogonadotropic hypogonadism.

  4. GNRHR (and GNRH) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites.

  5. first description of a GNRHR gene mutation in three patients diagnosed with polycystic ovary syndrome.

  6. We showed that GNRHR and LHCGR were highly expressed in some wildtype aldosterone-producing adenoma samples, and that they positively correlated with GnRH-stimulated aldosterone production.

  7. Results show that biallelic gonadotropin releasing hormone receptor (GNRHR) mutations are not a frequent cause of age-related androgen decline in men.

  8. GnRH receptors on triple negative breast cancer cells can be used for targeted therapy of these cancers with GnRH agonist triptorelin

  9. analysis of information transfer via gonadotropin-releasing hormone receptors to extracellular signal-regulated kinase or nuclear factor of activated T-cells

  10. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance

  11. Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG.

  12. A high prevalence of endometriosis, polymorphism in the LHCGR and GnRH1 and progonadoliberin-2 antibodies in serum was found among the patients with severe dysmotility after treatment with GnRH analogs.

  13. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes

  14. Mutations were found in the following genes in one or more patients with congenital hypogonadotropic hypogonadism: KAL1, FGFR1, GNRHR, and CHD7

  15. Mutations in GNRHR do not appear to be involved in the pathogenesis of constitutional delay of growth and puberty.

  16. GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of aldosterone-producing adenoma.

  17. Studies of the gonadotrope suggest that extracellular regulatory loops may play a central role in the regulation of gonadotropin gene expression by gonadotropin-releasing hormone (GnRH) receptor activation.

  18. Interaction between ER-associated Hsp40s and the Vps34 complex permits the selective degradation of ERAD-resistant membrane protein GNRHR via ERQC autophagy.

  19. A species specific motif participates in recognition of endoplasmic reticulum retention of the GnRHR by calnexin.

  20. GnRHI, GnRHII and GnRH receptor expression correlated significantly with poor prognosis in breast cancer patients

Rabbit Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. These results suggest that GNRHR-I is constitutively expressed in rabbit corpora lutea independently of luteal stage of pseudopregnant rabbits.

Mouse (Murine) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. GnRH receptorexpression levels depend on JUN and are critical for reproductive function.

  2. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA.

  3. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development.

  4. GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance.

  5. His305 of the GnRH receptor forms two distinct interactions that determine binding to GnRH and couple agonist binding to the conserved transmembrane domain network that activates GPCRs.

  6. The aims of this study were to explore whether mRNA-levels of gonadotropin-releasing hormone (Gnrh) and its receptor (Gnrhr) were changed in plaque-bearing Alzheimer's disease transgenic mice.

  7. Data confirm that Gnrhr mRNA and protein are expressed in ovaries, granulosa cells, cumulus cells, and oocytes.

  8. Msx1 functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU and GnRHR genes.

  9. These results suggest decreased GnRH receptor signaling in the mutant animal, compared with wild type.

  10. Report down-regulation of ErbB4 expression in hypothalamic neurons induced by G-protein-coupled gonadotropin releasing hormone receptor stimulation.

  11. GnRHR neurons were found in different brain areas. Many GnRHR neurons were identified in areas influencing sexual behaviors

  12. A comprehensive knowledgebase of the GnRHR signaling in the LbetaT2 cell, was curated.

  13. Null Gnrhr mice had small sexual organs, low levels of FSH, LH, and steroid hormones, failure of sexual maturation, infertility, and inability to respond to exogenous GnRH.

  14. GnRH and dex synergistically activate the endogenous GnRHR promoter in L beta T2 cells

  15. role of regulatory elements and their cognate transcription factors in transactivation of the mGnRHR gene

  16. an intact AP-1 element is necessary for GnRH responsiveness of the GnRHR gene; results suggest a critical role for JNK in mediating GnRH regulation of the GnRHR gene

  17. the GnRH receptor activating sequence is a composite regulatory element whose functional activity is dependent on the organization of a multi-protein complex consisting of Smads, AP-1 and a member of the forkhead family of DNA binding proteins

  18. Data suggest that activin receptor II signaling is critical only for follicle-stimulating hormone homeostasis and not for gonadotrophin-releasing hormone (GnRH)biosynthesis or induction of pituitary GnRH receptor expression.

  19. Results suggest that pituitary homeobox 1 (Pitx-1) can direct transactivation of the mouse gonadotropin-releasing hormone receptor gene, in part by DNA binding and in part by an action of Pitx-1 as a cofactor for AP-1 [Pitx-1].

  20. NF-Y and Oct-1 bind to the SURG-1 element to direct basal and GnRH-stimulated expression of the mGnRHR gene

Cow (Bovine) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. The GRIA1 polymorphism exists in beef cows but it does not influence antral follicle numbers. The association between GnRHR genotype and age at first calving is likely not causal as this polymorphism is not functional.

  2. There was a significant correlation between frequency profile and timing of puberty among the studied breeds, which seems to suggest that genetic variation within bovine GNRHR gene could explain at least part of the reported variability.

  3. These results indicate that GnRHR gene can be a potential marker for improving sperm quality traits, and imply that bulls with GA or CT genotype should be selected in breeding program.

  4. Seven sequence variants (SVs) have been identified in exon 1 and in the promoter region upstream of the bovine gonadotrophin releasing hormone (GnRH) receptor; g.-108T>C alteration was associated with beneficial effects on fertility

Rainbow Trout (Oncorhynchus mykiss) Gonadotropin-Releasing Hormone Receptor (GNRHR) interaction partners

  1. Data show that GnRH stimulates phagocytosis in fish leucocytes through a GnRH-receptor-dependent pathway.

  2. Gene expression regulation during sex maturation in male salmon.

GNRHR Protein Profile

Protein Summary

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Gene names and symbols associated with GNRHR

  • gonadotropin releasing hormone receptor (GNRHR)
  • gonadotropin releasing hormone receptor (Gnrhr)
  • gonadotropin releasing hormone receptor (gnrhr)
  • gonadotropin-releasing hormone receptor (gnrh-r)
  • GH1 protein
  • gnrh-r protein
  • GNRHR protein
  • GNRHR1 protein
  • GNRHR1/III protein
  • GNRHR2 protein
  • gnrhr3/ii protein
  • GRHR protein
  • HH7 protein
  • Lhrhr protein
  • LRHR protein
  • xgnrhr protein

Protein level used designations for GNRHR

gnRH receptor , gnRH-R , gonadotropin-releasing hormone (type 1) receptor 1 , leutinizing hormone releasing horomone receptor , leutinizing-releasing hormone receptor , luliberin receptor , type I GnRH receptor , GnRH receptor , gonadotropin-releasing hormone receptor , gonadotropin releasing hormone receptor , growth hormone , luteinizing-releasing hormone receptor , gnoadotropin releasing hormone receptor 2 , gonadotropin-releasing hormone II receptor , type 1/III gonadotropin-releasing hormone receptor hexahelical , type 3/II gonadotropin-releasing hormone receptor , pituitary GnRH receptor , pituitary gonadotropin-releasing hormone receptor , LHRH , luteinizing hormone-releasing hormone receptor

GENE ID SPECIES
2798 Homo sapiens
403718 Canis lupus familiaris
443413 Ovis aries
471226 Pan troglodytes
711577 Macaca mulatta
100009509 Oryctolagus cuniculus
100093333 Ornithorhynchus anatinus
100135532 Cavia porcellus
100589627 Nomascus leucogenys
14715 Mus musculus
81668 Rattus norvegicus
281798 Bos taurus
427517 Gallus gallus
100135417 Xenopus (Silurana) tropicalis
100136028 Oncorhynchus mykiss
100033874 Equus caballus
397515 Sus scrofa
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