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Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. Additionally we are shipping Granzyme B Antibodies (289) and Granzyme B Kits (83) and many more products for this protein.
Showing 10 out of 39 products:
our exploratory study suggests that EOMES, BCL6 and GZMB gene expression are aberrant within the PB T cell transcriptome of HT patients. The association of this transcription signature with the heterogeneity of HT and disease control is suggested.
Serum interleukin 1 receptor antagonist (IL1RA) and granzyme B (GZMB) levels were markedly increased in Crohn's disease (CD) patients, suggesting that these markers can serve as biomarkers to identify gut inflammation.
Authors found that R(48)-GzmB is a stable protein that accumulates to similar levels in activated NK cells as Q(48)-GzmB. rs8192917 polymorphism may influence antitumor activity and the effect of antitumor cellular immunotherapy.
GzmA and gzmB were predominantly expressed by natural killer cells, and during abdominal sepsis, the percentage of these cells expressing gzms in peritoneal lavage fluid decreased, while the amount of expression in the gzm(+) cells increased
Study provides evidence that Il10 (show IL10 Proteins) expression is limited to migratory CD25 (show IL2RA Proteins)++ regulatory T cells only.
Long-term lung function decline in asthma is associated with elevation of bronchial CD8 and CD4 at baseline, and CD8, CD3 and granzyme B at follow-up
Granzyme B breaches the inner membrane through Tim22 (show TIMM22 Proteins), the metabolite carrier translocase pore, in a mitochondrial heat-shock protein 70 (show HSP70 Proteins)-dependent manner.
Differential proteomics were used to identify granzyme B substrates in three unrelated bacteria: Escherichia coli, Listeria monocytogenes, and Mycobacteria tuberculosis. Granzyme B cleaves a highly conserved set of proteins in all three bacteria, which function in vital biosynthetic and metabolic pathways that are critical for bacterial survival under diverse environmental conditions.
Proteolysis by granzyme B enhances presentation of autoantigenic PAD4 (show PADI4 Proteins) epitopes in rheumatoid arthritis.
our results suggest granzyme B PET imaging can serve as a quantitatively useful predictive biomarker for efficacious responses to cancer immunotherapy.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
, T-cell serine protease 1-3E
, cathepsin G-like 1
, cytotoxic T-lymphocyte proteinase 2
, cytotoxic serine protease B
, fragmentin 2
, granzyme B
, human lymphocyte protein