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The protein encoded by GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Additionally we are shipping Growth Differentiation Factor 10 Antibodies (88) and Growth Differentiation Factor 10 Kits (40) and many more products for this protein.
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Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 (show TGFBR3 Proteins) which shares the signaling inhibiting epithelial-mesenchymal transition.
GDF10 is a stroke-induced signal for axonal sprouting and functional recovery.
new hypoxia-inducible and SOX9 (show SOX9 Proteins)-regulated genes, Gdf10 and Chm-I (show LECT1 Proteins). In addition, Mig6 (show ERRFI1 Proteins) and InhbA (show INHBA Proteins) were induced by hypoxia, predominantly via HIF-2alpha (show EPAS1 Proteins)
BMP3b and BMP6 (show BMP6 Proteins) genes were suppressed by DNA methylation (show HELLS Proteins) and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs.
Results show that Gdf10, expressed in Bergmann glial cells, is affected by the loss of Shh (show SHH Proteins) as early as E18.5, suggesting a regulation of glial development by Shh (show SHH Proteins)
Here we show that Runx2 (show RUNX2 Proteins) is highly expressed in lung cancer cells and downregulates BMP-3B. The ectopic expression of Runx2 (show RUNX2 Proteins), but not DNA binding mutant Runx2 (show RUNX2 Proteins), in normal lung fibroblast cells and lung cancer cells resulted in suppression of BMP-3B levels.
data suggest that BMP-3b is secreted from adipocytes, is involved in adipocyte differentiation, and inhibits adipogenesis as a unique complex.
Sca-1 attenuated GDF10-dependent TGF-beta (show TGFB1 Proteins) signaling by disrupting the heterodimerization of TbetaRI (show TGFBR1 Proteins) and TbetaRII receptors.
Gdf10 is expressed in Bergmann glia and is reduced in staggerer mice.
GDF10 gene might have potential effects on body measurement traits in the above mentioned cattle populations and could be used for marker-assisted selection.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.
growth differentiation factor 10
, bone morphogenetic protein 3B-like
, bone morphogenetic protein 3B
, bone-inducing protein
, prepro bone inducing protein
, growth/differentiation factor 10