anti-Growth Factor, Augmenter of Liver Regeneration (GFER) Antibodies

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. Additionally we are shipping GFER Kits (19) and GFER Proteins (18) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GFER 2671 P55789
GFER 27100 Q63042
GFER 11692 P56213
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-GFER Antibodies at antibodies-online.com

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Hepatopoietin Antibody (Center) in HepG2 cell line lysates (35ug/lane). This demonstrates the GFER antibody detected the GFER protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded mouse stomach using GFER antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
$334.77
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometric analysis of HepG2 cells using Hepatopoietin Antibody (C-term) Cat.-No AP51820PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of Hepatopoietin Antibody (C-term) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the GFER antibody detected the GFER protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB GFER Antibody (Center) (ABIN655148) western blot analysis in mouse NIH-3T3 cell line lysates (35 µg/lane). This demonstrates the GFER antibody detected the GFER protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Mouse Rabbit Un-conjugated FACS, WB GFER Antibody (C-term) (ABIN655619) western blot analysis in mouse NIH-3T3 cell line lysates (35 µg/lane). This demonstrates the GFER antibody detected the GFER protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Western Blot (WB) analysis of HBE cells using ALR Polyclonal Antibody. 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: GFER/ALR Antibody [NBP1-90187] - Staining of human cell line U-2 OS shows positivity in cytoplasm & mitochondria. Western Blot: GFER/ALR Antibody [NBP1-90187] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Liver lysate; Primary Ab: 1µg/ml Rabbit Anti-Mouse GFER Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant protein. 100 μg Log in to see 13 to 16 Days
$360.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB 200 μL Log in to see 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: GFER/ALR Antibody  - Staining of human cell line A549 shows localization to cytosol & mitochondria. 100 μL Log in to see 10 to 13 Days
$491.63
Details

Top referenced anti-GFER Antibodies

  1. Human Polyclonal GFER Primary Antibody for ICC, IF - ABIN4313990 : Ferecatu, Gonçalves, Golinelli-Cohen, Clémancey, Martelli, Riquier, Guittet, Latour, Puccio, Drapier, Lescop, Bouton: The diabetes drug target MitoNEET governs a novel trafficking pathway to rebuild an Fe-S cluster into cytosolic aconitase/iron regulatory protein 1. in The Journal of biological chemistry 2014 (PubMed)

More Antibodies against GFER Interaction Partners

Human Growth Factor, Augmenter of Liver Regeneration (GFER) interaction partners

  1. Data (including data from studies in knockout mice) suggest that KIBRA (show WWC1 Antibodies) plays important role in regulating HPO activity, YAP (show YAP1 Antibodies) signaling, and actin cytoskeletal dynamics in podocytes; expression of KIBRA (show WWC1 Antibodies) and YAP (show YAP1 Antibodies) plus phosphorylation of YAP (show YAP1 Antibodies) are up-regulated in glomeruli of patients with focal segmental glomerulosclerosis. (KIBRA (show WWC1 Antibodies) = kidney/brain protein-KIBRA (show WWC1 Antibodies); HPO = hepatopoietin protein; YAP (show YAP1 Antibodies) = Yes associated protein-1 (show YAP1 Antibodies))

  2. Loss of DLG5 (show DLG5 Antibodies) expression promoted breast cancer progression by inactivating the Hippo signaling pathway and increasing nuclear YAP (show YAP1 Antibodies).

  3. WWC2 functions as a tumor suppressor by negatively regulating the Hippo signaling pathway and may serve as a prognostic marker in hepatocellular carcinoma.

  4. the results of this study demonstrated that targeted inhibition of the ALR expression in Jurkat cells triggered cell growth inhibition and sensitized cells to VCR via promoting apoptosis and regulating the cell cycle.

  5. IKBKE (show IKBKE Antibodies) plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway.

  6. we found 2 additional patients carrying compound heterozygous variants in GFER. Reverse phenotyping confirmed the phenotypical similarities between the 4 patients. Together with the first literature reports, the review of these 8 cases from 4 unrelated families enables us to better describe this apparently homogeneous disorder, with the clinical and biological stigmata of mitochondrial disease

  7. ese findings collectively indicate that ALR negatively regulates the autophagy process through an association with the AMPK (show PRKAA1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling pathway. Autophagy inhibit apoptosis and play a protective role under conditions of oxidative stress.

  8. HPO interaction with MOB1 (show MOBKL3 Antibodies) is not essential for development and tissue growth control.

  9. Overexpression of augmenter of liver regeneration (ALR) in liver cancer was studied and found to improve sensitivity to antitumor drugs by increasing the retention of intracellular drugs, at least partly through the modulation of the ABCB1 (show ABCB1 Antibodies) and ABCG2 signaling pathway.

  10. ALR protects steatotic hepatocytes from ischemia reperfusion injury by attenuating oxidative stress and mitochondrial dysfunction.

Mouse (Murine) Growth Factor, Augmenter of Liver Regeneration (GFER) interaction partners

  1. To test whether differences in the ratio between CHCHD4 (show CHCHD4 Antibodies) and ALR might explain tissue-specific differences in the CHCHD4 (show CHCHD4 Antibodies) redox state, we determined the molar ratio of both proteins in different mouse tissues. Surprisingly, ALR is superstoichiometric over CHCHD4 (show CHCHD4 Antibodies) in most tissues.

  2. The exogenous expression of hepatic stimulator substance (HSS (show PANK2 Antibodies) was renamed augmenter of liver regeneration ALR) protected the liver from steatosis in mice with nonalcoholic steatohepatitis.

  3. this study shows that ALR can weaken ConA-induced hepatitis

  4. ALR is apparently required to ensure appropriate liver regeneration following PH in mice, and deletion of the ALR gene may delay liver regeneration in part due to impaired mitochondrial biogenesis.

  5. ALR can protect mice against acute liver injury by up-regulating the expression of regulatory T cells.

  6. From weeks 2-4 after birth, levels of steatosis and apoptosis decreased in ALR-L-KO mice, and numbers of ALR-expressing cells increased, along with ATP level

  7. As a mechanism, we suggest a direct protective effect of ALR on apoptotic and necrotic death of hepatocytes and an attenuation of inflammatory cell influx into the postischemic tissue.

  8. ALR may serve as a potential diagnostic marker of hepatocellular stress and/or acute inflammatory conditions.

  9. Growth factor erv1-like (Gfer) inhibits the COP9 (show COPS8 Antibodies) signalosome subunit jun activation-domain binding protein 1 (Jab1 (show COPS5 Antibodies))-mediated degradation of the cyclin-dependent kinase inhibitor p27(kip1 (show CDKN1B Antibodies)) to restrict proliferation of hematopoietic stem cells.

  10. Gfer plays an essential pro-survival role in the maintenance of murine embryonic stem cell pluripotency by preserving the structural and functional integrity of their mitochondria, through modulation of the key mitochondrial fission factor (show MFF Antibodies) Drp1 (show CRMP1 Antibodies).

GFER Antigen Profile

Protein Summary

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.

Gene names and symbols associated with GFER

  • growth factor, augmenter of liver regeneration (GFER) antibody
  • growth factor, augmenter of liver regeneration (Gfer) antibody
  • growth factor, augmenter of liver regeneration L homeolog (gfer.L) antibody
  • Alr antibody
  • ERV1 antibody
  • HERV1 antibody
  • HPO antibody
  • HPO1 antibody
  • HPO2 antibody
  • HSS antibody

Protein level used designations for GFER

ERV1 homolog , FAD-linked sulfhydryl oxidase ALR , erv1-like growth factor , hepatic regenerative stimulation substance , hepatopoietin protein , augmenter of liver regeneration , growth factor, erv1 homolog , growth factor, erv1-like (augmenter of liver regeneration) , growth factor, augmenter of liver regeneration , growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)

GENE ID SPECIES
2671 Homo sapiens
27100 Rattus norvegicus
479885 Canis lupus familiaris
618423 Bos taurus
694203 Macaca mulatta
733269 Xenopus laevis
750034 Pan troglodytes
11692 Mus musculus
Selected quality suppliers for anti-GFER (GFER) Antibodies
Did you look for something else?