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GNB1L encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. Additionally we are shipping Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 1-Like Antibodies (33) and and many more products for this protein.
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mRNA expression results implies that the GNB1L high-expression allele is the risk allele for schizophrenia and bipolar disorder in the Han Chinese population.
The results of this study suggested that GNB1L is linked with bipolar disorder and schizophrenia and not with major depressive disorder.
Beta-blocker therapy and heart rate control during exercise testing in the general population: role of GNB1L variant.
The present findings support assertions that GNB1L is one of the genes in the 22q11DS region responsible for increasing the risk of schizophrenia.
markers associated with psychosis are also correlated with alterations in GNB1L expression, raising the hypothesis that the risk to develop psychosis at this locus could be mediated in a dose sensitive manner via gene expression
GbetaL is involved in the negative regulation of TNFalpha-stimulated NF-kappaB signaling through a direct interaction with IKK.
This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene.
G-protein beta subunit-like protein
, WD repeat-containing protein 14
, WD40 repeat-containing protein deleted in VCFS
, g protein subunit beta-like protein 1
, guanine nucleotide binding protein beta-subunit-like polypeptide
, guanine nucleotide-binding protein subunit beta-like protein 1
, guanine nucleotide binding protein (G protein), beta polypeptide 1-like