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Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. Additionally we are shipping GMPR2 Antibodies (32) and GMPR2 Kits (3) and many more products for this protein.
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Loss of expression of GMPR2 and PPARalpha (show PPARA Proteins) is associated with breast cancer basal phenotype; indicating that they may play a role in carcinogenesis.
A single crystal structure of human GMPR (show GMPR Proteins) type 2 with IMP (show IMPA1 Proteins) and NADPH (show NQO1 Proteins) fortuitously captures three different states, each of which mimics a distinct step in the catalytic cycle of guanosine monophosphate reductase(GMPR (show GMPR Proteins)).
Data suggest the existence of two distinct types of human GMP (show NT5C2 Proteins) reductase molecular species, which can be used to explain the bimodal saturation curve noted with purified human erythrocyte GMP (show NT5C2 Proteins) reductase.
GMPR2 is a novel human GMP (show NT5C2 Proteins) reductase, and overexpression of GMPR2 can promote the monocytic differentiation of HL-60 leukemia cells.
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation (By similarity).
guanosine monophosphate reductase 2
, GMP reductase 2
, guanosine 5'-monophosphate oxidoreductase 2
, guanosine monophosphate reductase isolog
, GMP reductase 2 (Guanosine 5-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2)