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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Additionally we are shipping H2AFY Antibodies (29) and many more products for this protein.
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The Skp2-mH2A1-CDK8 (show CDK8 Proteins) axis has a critical role in breast cancer development via dysregulation of the G2/M transition, polyploidy, cell growth dysregulation, and loss of tumor suppression.
We show that composite nucleosomes containing mH2A and NRF-1 (show NFE2L1 Proteins) are stably positioned on gene regulatory regions and can buffer transcriptional noise associated with antiviral responses
High MacroH2A1 expression is associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis.
macroH2A1.1 expression correlates with poor survival of triple-negative breast cancer patients
MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation.
MacroH2A1 specifically recruits PELP1 (show PELP1 Proteins) to the promoters of macroH2A1 target genes, but macroH2A1 occupancy occurs independent of PELP1 (show PELP1 Proteins). This recruitment allows macroH2A1 and PELP1 (show PELP1 Proteins) to cooperatively regulate gene expression outcomes.
The results demonstrate that macroH2A1 is a new factor involved in the regulation of rDNA transcription.
macro histone variants (macroH2A) are expressed at low levels in stem cells and are up-regulated during differentiation
Both macroH2A1 isoforms may play a role in hepatocellular carcinoma pathogenesis and may be considered as novel diagnostic markers for human hepatocellular carcinoma.
MacroH2A1 splicing isoforms differentially regulate the transcription of a set of genes involved in redox metabolism.
These data indicate that macroH2A1.1-containing chromatin regulates mitochondrial respiration by limiting nuclear NAD(+) consumption and establishing a buffer of NAD(+) precursors in differentiated cells.
Both histone H3 (show HIST3H3 Proteins) lysine 27 acetylation and recruitment of the transcription factor Pbx1 (show PBX1 Proteins) at prospective enhancers are regulated by mH2A1.2.
tumor suppressive histone variant macroH2A1 is a critical component of the positive feedback loop that maintains the cell senescence-associated secretory phenotype, including activation of ATM (show ATM Proteins)
The macroH2A, a critical component of chromatin, suppresses the development of melanoma through regulating cyclin D1 (show CCND1 Proteins), cyclin D3 (show CCND3 Proteins) and CDK6 (show CDK6 Proteins) genes.
Data show that MacroH2A.1 and macroH2A.2 regulate gene expression with them acting synergistically on the expression of some genes and apparently having opposing effects on others.
Both macroH2A1 isoforms may play a role in hepatocellular carcinoma pathogenesis.
macroH2A1 and macroH2A2 (show H2AFY2 Proteins), together with histone 3 lysine 27 methylated 3, co-occupy pluripotency genes in wild-type (wt) fibroblasts.
macroH2A1 is a critical chromatin component that regulates the delicate balance between self-renewal and differentiation of embryonic and adult stem cells
macroH2A may help maintain the long-term stability of the differentiated state of somatic cells.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
H2A histone family, member Y
, core histone macro-H2A.1
, histone macroH2A1
, histone macroH2A1.2
, histone H2A.y
, histone macroH2A1.1
, medulloblastoma antigen MU-MB-50.205