HBS1-Like (S. Cerevisiae) (HBS1L) ELISA Kits

HBS1L encodes a member of the GTP-binding elongation factor family. Additionally we are shipping HBS1-Like (S. Cerevisiae) Antibodies (76) and HBS1-Like (S. Cerevisiae) Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human HBS1L HBS1L 10767 Q9Y450
Anti-Mouse HBS1L HBS1L 56422 Q69ZS7
Anti-Rat HBS1L HBS1L 293408 Q6AXM7
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More ELISA Kits for HBS1-Like (S. Cerevisiae) Interaction Partners

Human HBS1-Like (S. Cerevisiae) (HBS1L) interaction partners

  1. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development.

  2. Knowledge of the interacting residues in the yeast complexes allowed identification of a splice variant of human HBS1-Like as a Ski7-like exosome-binding protein, revealing the evolutionary conservation of this cytoplasmic cofactor.

  3. high-risk genotypes of six Hb F-associated SNPs, rs9376090, rs7776054, rs9399137, rs9389268, rs9402685 in the HBS1L-MYB (show MYB ELISA Kits) intergenic region and rs189984760 in the BCL11A (show BCL11A ELISA Kits) locus, showed association with high Hb F levels

  4. The HBS1L-MYB (show MYB ELISA Kits) region contains two HbF QTLs, HMIP (show MIPEP ELISA Kits)-2A and HMIP (show MIPEP ELISA Kits)-2B (HBS1L-MYB (show MYB ELISA Kits) intergenic polymorphisms A and B) HMIP (show MIPEP ELISA Kits)-A is tagged by the SNP rs9399137, with the C" allele promoting HbF. Only 1 sickle cell patient had this allele. HMIP (show MIPEP ELISA Kits)-B was tagged in these patients by rs4895441and represented Amerindian ethnic origin.

  5. we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3

  6. eRF3 neither interacts with the rRNA ribosephosphate backbone nor dissociates from the complex after GTP (show AK3 ELISA Kits) hydrolysis at translation termination.

  7. The study compares polymorphism at BCL11A (show BCL11A ELISA Kits) to HBS1L-MYB (show MYB ELISA Kits) loci and explains less of the variance in HbF in patients with sickle cell disease in Cameroon.

  8. Genetic variants of HBS1L is associated with sickle cell disease.

  9. Several HBS1L-MYB (show MYB ELISA Kits) intergenic variants reduce transcription factor binding, affecting interactions with MYB (show MYB ELISA Kits) and MYB (show MYB ELISA Kits) expression levels. This may explain the genetic association of HBS1L-MYB (show MYB ELISA Kits) intergenic polymorphisms with erythroid traits and HbF levels.

  10. The non-stop (show USP22 ELISA Kits) decay mechanism exists in mammalian cells and involves Hbs1, Dom34, and the exosome-Ski (show SKI ELISA Kits) complex.

HBS1-Like (S. Cerevisiae) (HBS1L) Antigen Profile

Antigen Summary

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Gene names and symbols associated with HBS1L

  • HBS1 like translational GTPase (HBS1L) antibody
  • elongation factor 1 alpha like protein (SJAG_02601) antibody
  • HBS1-like (S. cerevisiae) (hbs1l) antibody
  • eukaryotic translation elongation factor 1 alpha 1, like 1 (eef1a1l1) antibody
  • HBS1 like translational GTPase L homeolog (hbs1l.L) antibody
  • HBS1-like translational GTPase (hbs1l) antibody
  • Hbs1-like (S. cerevisiae) (Hbs1l) antibody
  • HBS1-like translational GTPase (Hbs1l) antibody
  • HBS1-like (S. cerevisiae) (HBS1L) antibody
  • 2810035F15Rik antibody
  • AI326327 antibody
  • chunp6927 antibody
  • eef1a antibody
  • EF-1a antibody
  • ef1a antibody
  • EFL1-alpha antibody
  • eRFS antibody
  • HBS1 antibody
  • HSPC276 antibody
  • ik:tdsubc_2a3 antibody
  • ik:tdsubc_2b3 antibody
  • tdsubc_2a3 antibody
  • wu:fa91c07 antibody
  • wu:fa94b03 antibody
  • wu:fc23c07 antibody
  • wu:fi13b09 antibody
  • xx:tdsubc_2a3 antibody
  • xx:tdsubc_2b3 antibody
  • zgc:55400 antibody

Protein level used designations for HBS1L

HBS1-like (S. cerevisiae) , HBS1-like protein , EF-1-alpha , ef-1 alpha , elongation factor 1-alpha , ERF3-similar protein , Hsp70 subfamily B suppressor 1-like protein , eukaryotic release factor 3

463015 Pan troglodytes
7047708 Schizosaccharomyces japonicus yFS275
100173449 Pongo abelii
100195249 Salmo salar
30516 Danio rerio
444278 Xenopus laevis
324267 Danio rerio
421694 Gallus gallus
10767 Homo sapiens
476211 Canis lupus familiaris
541083 Bos taurus
56422 Mus musculus
293408 Rattus norvegicus
100155814 Sus scrofa
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